Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.43 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.43 |
| ▸ | F10 | P00742 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 9/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3024357 | 0.90 | MAPT (0.48) | F10MAPTALDH1A1TSHRKMT2A | |
| SCHEMBL3033844 | 0.85 | CCR2 (0.40) | MAPT | |
| SCHEMBL3024131 | 0.83 | ECE1 (0.34) | MAPTNAMPTMAP2K2MAP2K1 | |
| SCHEMBL4907168 | 0.79 | MAPT (0.51) | NOD2NOD1F10MAPTKDM4E | |
| SCHEMBL3034236 | 0.79 | CYP2C9 (0.48) | MAP2K2MAP2K1 | |
| SCHEMBL2811033 | 0.78 | F10 (0.56) | NOD2NOD1F10MAPTKDM4E | |
| SCHEMBL3039673 | 0.77 | MAP2K1 (0.42) | MAPTTDP1MEN1KMT2AMAP2K2 | |
| SCHEMBL12083414 | 0.76 | MAP2K1 (0.50) | MAPK1MAP2K2MAP2K1 | |
| SCHEMBL12085726 | 0.74 | KCNH2 (0.40) | MAPTMAP2K1 | |
| SCHEMBL2945848 | 0.74 | ALDH1A1 (0.44) | NOD2NOD1MAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2164850-B1 | N-SUBSTITUTED AZAINDOLES AND METHODS OF USE | GENENTECH INC (US) | 2016-01-13 | — | — | EP | disclosed |
| EP-2164850-B1 | N-SUBSTITUTED AZAINDOLES AND METHODS OF USE | GENENTECH INC (US) | 2016-01-13 | — | — | EP | disclosed |
| US-8258152-B2 | N-substituted azaindoles and methods of use | GENENTECH, INC. (US) | 2012-09-04 | — | — | US | disclosed |
| US-20100216768-A1 | N-SUBSTITUTED AZAINDOLES AND METHODS OF USE | GENENTECH, INC. | 2010-08-26 | — | — | US | disclosed |
| EP-2164850-A2 | N-SUBSTITUTED AZAINDOLES AND METHODS OF USE | Genetech, Inc. (US) | 2010-03-24 | — | — | EP | disclosed |
| WO-2008157179-A2 | N-SUBSTITUTED AZAINDOLES AND METHODS OF USE | GENENTECH, INC. (US) | 2008-12-24 | — | — | WO | disclosed |
| WO-2008157179-A2 | N-SUBSTITUTED AZAINDOLES AND METHODS OF USE | GENENTECH, INC. (US) | 2008-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216768-A1 | N-SUBSTITUTED AZAINDOLES AND METHODS OF USE | MKI67, CCNI, CDKN1A | NOD2 1894/4885NOD1 1716/4885F10 4216/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.