SCHEMBL3023692

SCHEMBL3023692

O=C(O)C1(Cc2ccccc2)C2CC3CC(C2)CC1C3

nearest known ligand 0.62

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 9/20 0.62
EPHX2 P34913 3/20 0.44
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44
HPGD P15428 1/20 0.43
P2RX7 Q99572 2/20 0.42
MAPK1 P28482 1/20 0.42
CYP3A4 P08684 1/20 0.39
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13216481 0.84 HSD11B1 (0.53) HSD11B1MEN1KMT2AP2RX7
SCHEMBL13216484 0.83 HSD11B1 (0.64) HSD11B1EPHX2HPGDP2RX7MAPK1
SCHEMBL13216317 0.80 HSD11B1 (0.67) HSD11B1EPHX2MEN1KMT2AP2RX7
SCHEMBL13216325 0.77 HSD11B1 (1.00) HSD11B1EPHX2MEN1KMT2AHPGD
SCHEMBL17356681 0.77 HSD11B1 (0.58) HSD11B1EPHX2MEN1KMT2AHPGD
SCHEMBL17082681 0.75 HSD11B1 (0.44) HSD11B1MEN1KMT2AHPGDCYP3A4
SCHEMBL15922992 0.73 HSD11B1 (0.54) HSD11B1
SCHEMBL15922990 0.73 HSD11B1 (0.54) HSD11B1
SCHEMBL14300035 0.71 HSD11B1 (0.52) HSD11B1EPHX2MEN1KMT2AHPGD
SCHEMBL7057795 0.70 HSD11B1 (0.51) HSD11B1EPHX2MEN1KMT2AHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2054368-B1 CYCLIC 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2015-09-16 EP disclosed
US-8299054-B2 Cyclic 11-beta hydroxysteroid dehydrogenase type 1 inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2012-10-30 US disclosed
US-8299054-B2 Cyclic 11-beta hydroxysteroid dehydrogenase type 1 inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2012-10-30 US disclosed
US-8299054-B2 Cyclic 11-beta hydroxysteroid dehydrogenase type 1 inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2012-10-30 US disclosed
US-20100204199-A1 CYCLIC 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2010-08-12 US disclosed
US-20100204199-A1 CYCLIC 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2010-08-12 US disclosed
US-20100204199-A1 CYCLIC 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2010-08-12 US disclosed
US-7727978-B2 Cyclic 11-beta hydroxysteroid dehydrogenase type I inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2010-06-01 US disclosed
US-7727978-B2 Cyclic 11-beta hydroxysteroid dehydrogenase type I inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2010-06-01 US disclosed
US-7727978-B2 Cyclic 11-beta hydroxysteroid dehydrogenase type I inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2010-06-01 US disclosed
EP-2054368-A2 CYCLIC 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS Brystol-Myers Squibb Company (US) 2009-05-06 EP disclosed
US-20080234249-A1 CYCLIC 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2008-09-25 US disclosed
US-20080234249-A1 CYCLIC 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2008-09-25 US disclosed
US-20080234249-A1 CYCLIC 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2008-09-25 US disclosed
WO-2008024892-A2 CYCLIC 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2008-02-28 WO disclosed
WO-2008024892-A2 CYCLIC 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2008-02-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080234249-A1 CYCLIC 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS HSD11B1, HSD17B1, HSD11B2 HSD11B1 1/4885EPHX2 650/4885MEN1 994/4885
US-20100204199-A1 CYCLIC 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS HSD11B1, HSD17B1, HSD11B2 HSD11B1 1/4885EPHX2 650/4885MEN1 994/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.