Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.50 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | DHPS | P49366 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28275793 | 0.86 | ADORA2A (0.56) | ADORA2AADORA1HSP90AA1HSP90AB1ALDH1A1 | |
| SCHEMBL28096992 | 0.74 | ADORA2A (0.51) | ADORA2AADORA1HSP90AA1HSP90AB1ALDH1A1 | |
| SCHEMBL7777502 | 0.73 | ADORA2A (0.57) | ADORA2AADORA1HSP90AA1HSP90AB1ALDH1A1 | |
| SCHEMBL4408835 | 0.73 | ADORA2A (0.60) | ADORA2AADORA1HSP90AA1HSP90AB1ALDH1A1 | |
| SCHEMBL28957218 | 0.72 | DHFR (0.51) | ADORA2AADORA1ALDH1A1HPGDLMNA | |
| SCHEMBL3678540 | 0.71 | HSP90AA1 (0.58) | ADORA2AADORA1HSP90AA1HSP90AB1ALDH1A1 | |
| SCHEMBL17022583 | 0.69 | ALDH1A1 (0.54) | ADORA2AADORA1HSP90AA1HSP90AB1ALDH1A1 | |
| SCHEMBL27881848 | 0.68 | ADORA2A (0.57) | ADORA2AADORA1HSP90AA1HSP90AB1ALDH1A1 | |
| SCHEMBL23851630 | 0.68 | KDM4E (0.36) | ADORA2AADORA1HSP90AA1HSP90AB1ALDH1A1 | |
| SCHEMBL7776147 | 0.68 | ADORA2A (0.57) | ADORA2AADORA1HSP90AA1HSP90AB1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230049557-A1 | NOVEL ADAMANTANE DERIVATIVES AS INHIBITORS OF FOCAL ADHESION KINASE | INCHEON NATIONAL UNIVERSITY RESEARCH & BUSINESS FOUNDATION (KR) | 2023-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230049557-A1 | NOVEL ADAMANTANE DERIVATIVES AS INHIBITORS OF FOCAL ADHESION KINASE | PTK2, DAPK2, DAPK1 | ADORA2A 767/4885ADORA1 828/4885HSP90AA1 1479/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.