Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CMKLR1 | Q99788 | 4/20 | 0.34 |
| ▸ | CTSS | P25774 | 2/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24012985 | 1.00 | BRD4 (0.38) | BRD4MAPTL3MBTL1HTR3ACYP1A2 | |
| SCHEMBL24013053 | 0.93 | BRD4 (0.40) | BRD4MAPTL3MBTL1HTR3ACMKLR1 | |
| SCHEMBL30242740 | 0.93 | BRD4 (0.40) | BRD4MAPTL3MBTL1HTR3ACMKLR1 | |
| SCHEMBL30242549 | 0.91 | BRD4 (0.38) | BRD4MAPTL3MBTL1HTR3ACYP1A2 | |
| SCHEMBL24012763 | 0.91 | BRD4 (0.38) | BRD4MAPTL3MBTL1HTR3ACYP1A2 | |
| SCHEMBL24012643 | 0.90 | BRD4 (0.38) | BRD4MAPTL3MBTL1HTR3ACMKLR1 | |
| SCHEMBL24013151 | 0.89 | BRD4 (0.41) | BRD4MAPTL3MBTL1HTR3ACMKLR1 | |
| SCHEMBL24012628 | 0.88 | FLT1 (0.41) | BRD4 | |
| SCHEMBL24012477 | 0.85 | BRD4 (0.38) | BRD4MAPTL3MBTL1HTR3ACYP1A2 | |
| SCHEMBL24013067 | 0.85 | BRD4 (0.41) | BRD4MAPTL3MBTL1HTR3ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4146658-A1 | NEW MACROCYCLIC LRRK2 KINASE INHIBITORS | Les Laboratoires Servier (FR) | 2023-03-15 | — | — | EP | disclosed |