Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Azd-7268. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 known ✓ | P41143 | 19/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 14/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.60 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Azd-7268 SCHEMBL474151 | 1.00 | OPRD1 (1.00) | OPRD1OPRM1KCNH2CXCR3 | |
| SCHEMBL474160 | 0.88 | OPRD1 (0.78) | OPRD1OPRM1KCNH2CXCR3 | |
| SCHEMBL12432542 | 0.84 | OPRD1 (0.72) | OPRD1OPRM1KCNH2CXCR3 | |
| SCHEMBL12432534 | 0.83 | OPRD1 (0.71) | OPRD1OPRM1KCNH2CXCR3 | |
| SCHEMBL474620 | 0.82 | OPRD1 (0.70) | OPRD1OPRM1KCNH2CXCR3 | |
| SCHEMBL14228324 | 0.80 | OPRD1 (0.67) | OPRD1OPRM1KCNH2CXCR3 | |
| SCHEMBL474169 | 0.79 | OPRD1 (0.65) | OPRD1OPRM1KCNH2 | |
| SCHEMBL474192 | 0.78 | OPRM1 (0.64) | OPRD1OPRM1CXCR3 | |
| SCHEMBL474252 | 0.77 | OPRM1 (0.62) | OPRD1OPRM1KCNH2CXCR3 | |
| SCHEMBL6191622 | 0.76 | OPRD1 (0.79) | OPRD1OPRM1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230077811-A1 | ACTIVATION OF NEUROPEPTIDE RECEPTORS ON PLASMACYTOID DENDRITIC CELLS TO TREAT OR PREVENT OCULAR DISEASES ASSOCIATED WITH NEOVASCULARIZATION AND INFLAMMATION | TRUSTEES OF TUFTS COLLEGE | 2023-03-16 | — | — | US | disclosed |