Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.63 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.63 |
| ▸ | PLA2G2A | P14555 | 5/20 | 0.61 |
| ▸ | HTR6 | P50406 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | PLA2G4A | P47712 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | PPARG | P37231 | 3/20 | 0.54 |
| ▸ | PPARD | Q03181 | 3/20 | 0.54 |
| ▸ | PPARA | Q07869 | 3/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.51 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.49 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3031169 | 0.92 | MTNR1A (0.64) | MTNR1AMTNR1BPLA2G2AHTR6LMNA | |
| SCHEMBL3019384 | 0.92 | MTNR1A (0.73) | MTNR1AMTNR1BPLA2G2AHTR6LMNA | |
| SCHEMBL3030239 | 0.89 | MTNR1A (0.61) | MTNR1AMTNR1BPLA2G2AHTR6LMNA | |
| SCHEMBL3033152 | 0.84 | MTNR1A (0.56) | MTNR1AMTNR1BPLA2G2AHTR6LMNA | |
| SCHEMBL3026213 | 0.84 | MTNR1A (0.60) | MTNR1AMTNR1BPLA2G2AHTR6LMNA | |
| SCHEMBL11332785 | 0.83 | MTNR1A (0.59) | MTNR1AMTNR1BPLA2G2AHTR6LMNA | |
| SCHEMBL3036311 | 0.83 | MTNR1A (0.74) | MTNR1AMTNR1BPLA2G2AHTR6LMNA | |
| SCHEMBL9096563 | 0.81 | PLA2G2A (0.80) | MTNR1AMTNR1BPLA2G2AHTR6LMNA | |
| SCHEMBL20769739 | 0.80 | PLA2G2A (0.83) | MTNR1AMTNR1BPLA2G2AHTR6LMNA | |
| SCHEMBL15242254 | 0.80 | MTNR1A (0.58) | MTNR1AMTNR1BPLA2G2AHTR6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7572806-B2 | PPAR active compounds | PLEXXIKON, INC. (US) | 2009-08-11 | — | — | US | claimed |
| US-20080096913-A1 | PPAR active compounds | PLEXXIKON, INC. | 2008-04-24 | — | — | US | claimed |
| EP-1648867-B1 | PPAR ACTIVE COMPOUNDS | PLEXXIKON INC (US) | 2013-09-04 | — | — | EP | disclosed |
| EP-1648867-B1 | PPAR ACTIVE COMPOUNDS | PLEXXIKON INC (US) | 2013-09-04 | — | — | EP | disclosed |
| US-8367828-B2 | PPAR active compounds | PLEXXIKON INC. (US) | 2013-02-05 | — | — | US | disclosed |
| US-8367828-B2 | PPAR active compounds | PLEXXIKON INC. (US) | 2013-02-05 | — | — | US | disclosed |
| US-8367828-B2 | PPAR active compounds | PLEXXIKON INC. (US) | 2013-02-05 | — | — | US | disclosed |
| US-20100210036-A1 | PPAR ACTIVE COMPOUNDS | PLEXXIKON, INC. | 2010-08-19 | — | — | US | disclosed |
| US-20100210036-A1 | PPAR ACTIVE COMPOUNDS | PLEXXIKON, INC. | 2010-08-19 | — | — | US | disclosed |
| US-20100210036-A1 | PPAR ACTIVE COMPOUNDS | PLEXXIKON, INC. | 2010-08-19 | — | — | US | disclosed |
| US-7723374-B2 | PPAR active compounds | PLEXXIKON, INC. (US) | 2010-05-25 | — | — | US | disclosed |
| US-20070149603-A1 | PPAR ACTIVE COMPOUNDS | PLEXXIKON, INC. | 2007-06-28 | — | — | US | disclosed |
| US-20070149603-A1 | PPAR ACTIVE COMPOUNDS | PLEXXIKON, INC. | 2007-06-28 | — | — | US | disclosed |
| US-20070149603-A1 | PPAR ACTIVE COMPOUNDS | PLEXXIKON, INC. | 2007-06-28 | — | — | US | disclosed |
| US-7202266-B2 | PPAR active compounds | PLEXXIKON, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-7202266-B2 | PPAR active compounds | PLEXXIKON, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| EP-1648867-A1 | PPAR ACTIVE COMPOUNDS | PLEXXIKON, INC. (US) | 2006-04-26 | — | — | EP | disclosed |
| US-20050288354-A1 | PPAR active compounds | PLEXXIKON, INC. | 2005-12-29 | — | — | US | disclosed |
| US-20050038246-A1 | PPAR active compounds | PLEXXIKON, INC. | 2005-02-17 | — | — | US | disclosed |
| WO-2005009958-A1 | PPAR ACTIVE COMPOUNDS | PLEXXIKON, INC. (US) | 2005-02-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080096913-A1 | PPAR active compounds | PPARG, PPARD, PPARA | MTNR1A 488/4885MTNR1B 384/4885PLA2G2A 938/4885 |
| US-20050038246-A1 | PPAR active compounds | PPARG, PPARD, PPARA | MTNR1A 488/4885MTNR1B 384/4885PLA2G2A 938/4885 |
| US-20050288354-A1 | PPAR active compounds | PPARG, PPARD, PPARA | MTNR1A 488/4885MTNR1B 384/4885PLA2G2A 938/4885 |
| US-20070149603-A1 | PPAR ACTIVE COMPOUNDS | PPARG, PPARD, PPARA | MTNR1A 488/4885MTNR1B 384/4885PLA2G2A 938/4885 |
| US-20100210036-A1 | PPAR ACTIVE COMPOUNDS | PPARG, PPARD, PPARA | MTNR1A 488/4885MTNR1B 384/4885PLA2G2A 938/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.