Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | GRM5 | P41594 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23884587 | 1.00 | MAPT (0.50) | MAPTNPC1MAPK1HTTLMNA | |
| SCHEMBL4085402 | 0.83 | HSD17B1 (0.43) | MAPTNPC1MAPK1HTTLMNA | |
| SCHEMBL4079530 | 0.79 | MAPT (0.48) | MAPTNPC1HTTLMNASMN1; SMN2 | |
| SCHEMBL23884641 | 0.78 | CASP1 (0.44) | MAPTNPC1MAPK1HTTLMNA | |
| SCHEMBL20157496 | 0.78 | HDAC1 (0.43) | MAPTNPC1MAPK1HTTPOLB | |
| SCHEMBL5382884 | 0.76 | MAPT (0.71) | MAPTNPC1MAPK1HTTLMNA | |
| SCHEMBL2821586 | 0.76 | MAPT (0.73) | MAPTNPC1MAPK1HTTLMNA | |
| SCHEMBL10954535 | 0.76 | MAPT (0.54) | MAPTNPC1MAPK1HTTLMNA | |
| SCHEMBL20157680 | 0.76 | POLB (0.42) | MAPTNPC1MAPK1HTTPOLB | |
| SCHEMBL8956307 | 0.75 | HDAC1 (0.53) | MAPTNPC1MAPK1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115715292-A | 1H-pyrazolo [4,3-g ] isoquinoline and 1H-pyrazolo [4,3-g ] quinoline derivatives as alpha-1-antitrypsin modulators for the treatment of alpha-1-antitrypsin deficiency (AATD) | 弗特克斯药品有限公司 | 2023-02-24 | — | — | CN | disclosed |