Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 15/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23884523 | 1.00 | GCGR (0.33) | GCGRMEN1KMT2APIK3R1PIK3CA | |
| SCHEMBL23884482 | 0.91 | MEN1 (0.33) | GCGRMEN1KMT2A | |
| SCHEMBL30251748 | 0.86 | DHODH (0.36) | MEN1KMT2A | |
| SCHEMBL23884451 | 0.86 | DHODH (0.36) | MEN1KMT2A | |
| SCHEMBL30251882 | 0.86 | GCGR (0.34) | GCGRMEN1KMT2A | |
| SCHEMBL23884584 | 0.86 | GCGR (0.34) | GCGRMEN1KMT2A | |
| SCHEMBL30251871 | 0.82 | ALDH1A1 (0.37) | GCGRMEN1KMT2A | |
| SCHEMBL23884553 | 0.82 | ALDH1A1 (0.37) | GCGRMEN1KMT2A | |
| SCHEMBL23884536 | 0.81 | PTGS2 (0.37) | MEN1KMT2A | |
| SCHEMBL30251904 | 0.81 | PTGS2 (0.37) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115715292-A | 1H-pyrazolo [4,3-g ] isoquinoline and 1H-pyrazolo [4,3-g ] quinoline derivatives as alpha-1-antitrypsin modulators for the treatment of alpha-1-antitrypsin deficiency (AATD) | 弗特克斯药品有限公司 | 2023-02-24 | — | — | CN | disclosed |