Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 10/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.32 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | DUT | P33316 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30544629 | 0.87 | NR1H2 (0.37) | NR1H2GABRG2GABRB3GABRA5DDB1 | |
| SCHEMBL30256654 | 0.86 | NR1H2 (0.48) | NR1H2GABRG2GABRB3GABRA5DDB1 | |
| SCHEMBL23392066 | 0.82 | NR1H2 (0.48) | NR1H2GABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL30754584 | 0.82 | NR1H2 (0.48) | NR1H2GABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL23391716 | 0.81 | GABRG2 (0.38) | NR1H2GABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL23391717 | 0.77 | HDAC3 (0.33) | DDB1CRBNHDAC3HDAC2HDAC6 | |
| SCHEMBL16597821 | 0.75 | GABRG2 (0.42) | NR1H2GABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL29773883 | 0.73 | CHRM2 (0.49) | NR1H2GABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL20581637 | 0.73 | GABRG2 (0.38) | NR1H2GABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL16597589 | 0.71 | PRMT5 (0.42) | GABRG2GABRB3GABRA5GABRA1GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4398941-A1 | BIFUNCTIONAL MOLECULES AS PROTEASOME STIMULATORS FOR IMPROVED TARGETED PROTEIN DEGRADATION, AND THEIR USES AS TARGETED BOOSTING DEGRADERS (TARBODS) | Booster Therapeutics GmbH (DE) | 2024-07-17 | — | — | EP | disclosed |
| CN-117940167-A | Bifunctional molecules as proteasome stimulators for improved targeted protein degradation and their use as targeted enhancing degradation agents (TARBOD) | 博思德医疗科技有限公司 | 2024-04-26 | — | — | CN | disclosed |
| WO-2023036936-A1 | BIFUNCTIONAL MOLECULES AS PROTEASOME STIMULATORS FOR IMPROVED TARGETED PROTEIN DEGRADATION, AND THEIR USES AS TARGETED BOOSTING DEGRADERS (TARBODS) | BOOSTER THERAPEUTICS GMBH (DE) | 2023-03-16 | — | — | WO | disclosed |