Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 13/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25187459 | 1.00 | KEAP1 (0.44) | KEAP1NFE2L2ATML3MBTL1NPSR1 | |
| SCHEMBL25264776 | 1.00 | KEAP1 (0.44) | KEAP1NFE2L2ATML3MBTL1NPSR1 | |
| SCHEMBL30256146 | 0.91 | KEAP1 (0.41) | KEAP1NFE2L2ATML3MBTL1NPSR1 | |
| SCHEMBL23959356 | 0.91 | KEAP1 (0.41) | KEAP1NFE2L2ATML3MBTL1NPSR1 | |
| SCHEMBL25555241 | 0.91 | KEAP1 (0.41) | KEAP1NFE2L2ATML3MBTL1NPSR1 | |
| SCHEMBL30256409 | 0.90 | PARP1 (0.43) | KEAP1NFE2L2ATML3MBTL1NPSR1 | |
| SCHEMBL30258583 | 0.90 | PARP1 (0.43) | KEAP1NFE2L2ATML3MBTL1NPSR1 | |
| SCHEMBL30533745 | 0.90 | KEAP1 (0.44) | KEAP1NFE2L2ATML3MBTL1NPSR1 | |
| SCHEMBL24174323 | 0.86 | KEAP1 (0.41) | KEAP1NFE2L2ATML3MBTL1NPSR1 | |
| SCHEMBL30533717 | 0.86 | KEAP1 (0.41) | KEAP1NFE2L2ATML3MBTL1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115667242-B | Tetrahydroisoquinoline compounds as NRF2 activators | 希四克斯探索有限公司 | 2025-02-28 | — | — | CN | disclosed |
| EP-4139295-A1 | TETRAHYDROISOQUINOLINE COMPOUNDS AS NRF2 ACTIVATORS | C4x Discovery Limited (GB) | 2023-03-01 | — | — | EP | disclosed |
| CN-115667242-A | Tetrahydroisoquinoline compounds as NRF2 activators | 希四克斯探索有限公司 | 2023-01-31 | — | — | CN | disclosed |