Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | PTGES2 | Q9H7Z7 | 6/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26731640 | 0.83 | CA1 (0.35) | KDM1ASIGMAR1PSEN1PSEN2APH1B | |
| SCHEMBL30261916 | 0.81 | VCAM1 (0.36) | KDM1ALMNAMAPT | |
| SCHEMBL21930412 | 0.81 | VCAM1 (0.36) | KDM1ALMNAMAPT | |
| SCHEMBL23442624 | 0.76 | KDM1A (0.39) | KDM1AMAPT | |
| SCHEMBL23442629 | 0.75 | USP2 (0.38) | KDM1ASIGMAR1LMNAMAPT | |
| SCHEMBL23669600 | 0.75 | KDM4C (0.40) | KDM1ASIGMAR1 | |
| SCHEMBL23442105 | 0.74 | KDM1A (0.39) | KDM1ASIGMAR1 | |
| SCHEMBL23670689 | 0.74 | KDM4C (0.37) | KDM1ASIGMAR1TSHR | |
| SCHEMBL23671128 | 0.74 | KDM4C (0.37) | KDM1ASIGMAR1 | |
| SCHEMBL23480816 | 0.74 | KDM1A (0.38) | KDM1ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4149947-A1 | SPIRO-SULFONAMIDE DERIVATIVES AS INHIBITORS OF MYELOID CELL LEUKEMIA-1 (MCL-1) PROTEIN | Prelude Therapeutics, Incorporated (US) | 2023-03-22 | — | — | EP | disclosed |