Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.50 |
| ▸ | PFKFB3 | Q16875 | 3/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31295947 | 0.86 | DYRK1A (0.69) | DYRK1AMKNK1MKNK2MAP4K4KDM4E | |
| SCHEMBL7705899 | 0.78 | KMT2A (0.57) | DYRK1AMAP4K4KDM4EALDH1A1HPGD | |
| SCHEMBL5751719 | 0.78 | HSP90AA1 (0.54) | DYRK1AMKNK1MKNK2KDM4EALDH1A1 | |
| SCHEMBL8265150 | 0.78 | ADORA2A (0.66) | TP53MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL31298725 | 0.78 | MKNK1 (0.46) | MAPTDYRK1AMKNK1MKNK2MAP4K4 | |
| SCHEMBL28338207 | 0.77 | CLK4 (0.61) | TP53MAPTDYRK1AKDM4EALDH1A1 | |
| SCHEMBL5753423 | 0.76 | MAPT (0.48) | TP53MAPTDYRK1AMKNK1MKNK2 | |
| SCHEMBL30577987 | 0.76 | ADORA2A (0.67) | MAPTKDM4EALDH1A1HPGDTSHR | |
| SCHEMBL30577982 | 0.76 | ADORA2A (0.67) | MAPTKDM4EALDH1A1HPGDTSHR | |
| SCHEMBL28029282 | 0.76 | CLK4 (0.65) | TP53MAPTDYRK1ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230047816-A1 | PFKFB3 INHIBITORS AND THEIR USES | GERO PTE. LTD. (SG) | 2023-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230047816-A1 | PFKFB3 INHIBITORS AND THEIR USES | PFKFB3, PFKFB4, PFKFB1 | TP53 2372/4885MAPT 845/4885DYRK1A 2727/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.