Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NEK1 | Q96PY6 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.39 |
| ▸ | HTR7 | P34969 | 4/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | HTR6 | P50406 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26213138 | 1.00 | NEK1 (0.44) | NEK1KDM4ELMNAGAAMAPT | |
| SCHEMBL26213160 | 0.87 | HTR1A (0.45) | NEK1KDM4ELMNAGAAMAPT | |
| SCHEMBL26213153 | 0.87 | NEK1 (0.42) | NEK1KDM4ELMNAGAAMAPT | |
| SCHEMBL26213188 | 0.82 | HTR1A (0.43) | NEK1KDM4ELMNAGAAMAPT | |
| SCHEMBL26213178 | 0.82 | HTR7 (0.47) | NEK1KDM4ELMNAGAAMAPT | |
| SCHEMBL26213146 | 0.81 | HTR1A (0.41) | NEK1KDM4ELMNAGAAMAPT | |
| SCHEMBL26213077 | 0.81 | KDM1A (0.47) | KDM4ELMNAGAAMAPTSMN1; SMN2 | |
| SCHEMBL26213157 | 0.80 | HTR1A (0.48) | SIGMAR1HTR7DRD2HTR6HTR1A | |
| SCHEMBL26213166 | 0.79 | HTR1A (0.41) | NEK1KDM4ELMNAGAAMAPT | |
| SCHEMBL26213056 | 0.79 | KDM1A (0.53) | SIGMAR1HTR7HTR1AKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115843271-B | Indole derivatives and their use for the treatment of cancer | 克洛德贝纳尔-里昂第一大学 | 2024-08-13 | — | — | CN | disclosed |
| EP-4175718-A1 | INDOLE DERIVATIVES AND USES THEREOF FOR TREATING A CANCER | UNIVERSITE CLAUDE BERNARD - LYON 1 (FR) | 2023-05-10 | — | — | EP | disclosed |
| CN-115843271-A | Indole derivatives and their use for the treatment of cancer | 克洛德贝纳尔-里昂第一大学 | 2023-03-24 | — | — | CN | disclosed |