Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.59 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 7/20 | 0.39 |
| ▸ | GSK3B | P49841 | 6/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 3/20 | 0.39 |
| ▸ | CDK2 | P24941 | 3/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3032900 | 0.90 | MAPKAPK2 (0.47) | MAPKAPK2KDM4EMEN1MAPTKMT2A | |
| SCHEMBL2411704 | 0.81 | MAPKAPK2 (0.67) | MAPKAPK2ROCK2ROCK1KDM4EMEN1 | |
| SCHEMBL27870411 | 0.73 | CFTR (0.49) | CFTRCDK1CDK2CCNB1CCNE1 | |
| SCHEMBL27886646 | 0.73 | CFTR (0.49) | MEN1KMT2ACFTRCDK1CDK2 | |
| SCHEMBL27870413 | 0.73 | XDH (0.58) | MEN1KMT2ACFTRCDK1CDK2 | |
| SCHEMBL27886637 | 0.72 | PI4KA (0.64) | CFTRCDK1CDK2CCNB1CCNE1 | |
| SCHEMBL28960375 | 0.71 | XDH (0.62) | KDM4ERAB9ACDK1CDK2CCNB1 | |
| SCHEMBL2435424 | 0.71 | MAPKAPK2 (0.48) | MAPKAPK2ROCK2ROCK1KDM4EMEN1 | |
| SCHEMBL3043474 | 0.71 | CFTR (0.38) | CFTRCDK1CDK2CCNB1CCNE1 | |
| SCHEMBL28230093 | 0.70 | CDK1 (0.48) | MEN1KMT2ACFTRCDK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111406-A2 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYRIAD PHARMACEUTICALS, INC. (US) | 2010-09-30 | — | — | WO | claimed |