Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 7/20 | 0.51 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.51 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21952088 | 1.00 | TSHR (0.51) | TSHRAPOBEC3AAPOBEC3GALDH1A1LMNA | |
| SCHEMBL21952063 | 0.88 | TSHR (0.62) | TSHRAPOBEC3AAPOBEC3GALDH1A1LMNA | |
| SCHEMBL29798204 | 0.83 | TSHR (0.61) | TSHRAPOBEC3AAPOBEC3GALDH1A1LMNA | |
| SCHEMBL30278740 | 0.80 | TSHR (0.52) | TSHRAPOBEC3AAPOBEC3GALDH1A1LMNA | |
| SCHEMBL21952071 | 0.80 | TSHR (0.52) | TSHRAPOBEC3AAPOBEC3GALDH1A1LMNA | |
| SCHEMBL21952015 | 0.79 | TSHR (0.70) | TSHRAPOBEC3AAPOBEC3GALDH1A1LMNA | |
| SCHEMBL30278759 | 0.79 | TSHR (0.70) | TSHRAPOBEC3AAPOBEC3GALDH1A1LMNA | |
| SCHEMBL31396264 | 0.78 | ALDH1A1 (0.55) | TSHRALDH1A1LMNAMAPK1KMT2A | |
| SCHEMBL21952059 | 0.78 | ALDH1A1 (0.55) | TSHRALDH1A1LMNAMAPK1KMT2A | |
| SCHEMBL21952032 | 0.78 | TSHR (0.63) | TSHRAPOBEC3AAPOBEC3GALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115768422-A | Ubiquitin ligase inhibitors for the treatment of cancer | 诺沃亚桑托斯教授基金会 | 2023-03-07 | — | — | CN | disclosed |