⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL656015 | 0.97 | CHRM1 (0.36) | — | |
| SCHEMBL69910 | 0.88 | — | — | |
| Ethylmalonate SCHEMBL107241 | 0.81 | — | — | |
| SCHEMBL8488441 | 0.80 | — | — | |
| SCHEMBL4318394 | 0.78 | CHRM1 (0.52) | — | |
| Ethylmalonate SCHEMBL108554 | 0.78 | HDAC1 (0.43) | — | |
| Ethylmalonate SCHEMBL9765245 | 0.78 | HDAC1 (0.43) | — | |
| Ethylmalonate SCHEMBL9118935 | 0.78 | HDAC1 (0.43) | — | |
| Ethylmalonate SCHEMBL5236397 | 0.78 | HDAC1 (0.43) | — | |
| Ethylmalonate SCHEMBL3157979 | 0.78 | HDAC1 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 90 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112851494-A | Preparation method of 1-pyrenebutyric acid | 苏州昊帆生物股份有限公司 | 2021-05-28 | — | — | CN | claimed |
| EP-4480480-A2 | SUBSTITUTED PYRROLO-PYRIDINONE DERIVATIVES AND THERAPEUTIC USES THEREOF | Bayer AG (DE) | 2024-12-25 | — | — | EP | disclosed |
| EP-4188551-B1 | ARYL SUBSTITUTED PYRROLO-PYRIDINONES AND THERAPEUTIC USES THEREOF | BAYER AG (DE) | 2024-12-18 | — | — | EP | disclosed |
| EP-4188929-B1 | SUBSTITUTED PYRROLO-PYRIDINONE DERIVATIVES AND THERAPEUTIC USES THEREOF | BAYER AG (DE) | 2024-10-02 | — | — | EP | disclosed |
| US-20230365554-A1 | SUBSTITUTED PYRROLO-PYRIDINONE DERIVATIVES AND THERAPEUTIC USES THEREOF | BAYER AKTIENGESELLSCHAFT (DE) | 2023-11-16 | — | — | US | disclosed |
| US-20230322767-A1 | ARYL SUBSTITUTED PYRROLO-PYRIDINONES AND THERAPEUTIC USES THEREOF | THE BROAD INSTITUTE, INC. | 2023-10-12 | — | — | US | disclosed |
| EP-4188929-A1 | SUBSTITUTED PYRROLO-PYRIDINONE DERIVATIVES AND THERAPEUTIC USES THEREOF | Bayer Aktiengesellschaft (DE) | 2023-06-07 | — | — | EP | disclosed |
| EP-4188551-A1 | ARYL SUBSTITUTED PYRROLO-PYRIDINONES AND THERAPEUTIC USES THEREOF | Bayer Aktiengesellschaft (DE) | 2023-06-07 | — | — | EP | disclosed |
| US-20220218676-A1 | CHROMANE, ISOCHROMANE AND DIHYDROISOBENZOFURAN DERIVATIVES AS mGluR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME CORP. (US) | 2022-07-14 | — | — | US | disclosed |
| EP-3519416-B1 | CHROMANE, ISOCHROMANE AND DIHYDROISOBENZOFURAN DERIVATIVES AS MGLUR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME (US) | 2021-03-31 | — | — | EP | disclosed |
| US-6699881-B2 | MATRIX METALLOPROTEASE INHIBITORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2004-03-02 | — | — | US | disclosed |
| US-20030078253-A1 | Thiol compounds, their production and use | TAKEDA PHARMACEUTICAL COMPANY, LIMITED (JP) | 2003-04-24 | — | — | US | disclosed |
| US-6420415-B1 | Thiol compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1132379-A1 | NOVEL THIOL DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND UTILIZATION THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2001-09-12 | — | — | EP | disclosed |
| US-6153705-A | CHAIN-END FUNCTIONALIZED BY ALKYL XANTHATES. | RHODIA CHIMIE (FR) | 2000-11-28 | — | — | US | disclosed |
| EP-0652208-B1 | Phenylalkan(en)oic acids with leukotriene B4 antagonistic activity | ONO PHARMACEUTICAL CO (JP) | 1998-01-14 | — | — | EP | disclosed |
| EP-0652208-A1 | Phenylalkan(en)oic acids with leukotriene B4 antagonistic activity | ONO PHARMACEUTICAL CO., LTD. (JP) | 1995-05-10 | — | — | EP | disclosed |
| US-4336380-A | FOR USE AS HYPOTENSIVE AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1982-06-22 | — | — | US | disclosed |
| EP-0034951-A2 | Photographic emulsions and elements containing blocked 5-pyrazolone magenta dye-forming couplers | EASTMAN KODAK COMPANY (a New Jersey corporation) (US) | 1981-09-02 | — | — | EP | disclosed |
| US-4276417-A | TREATMENT OF VASCULAR-CONDITION HYPERTENSION | HOFFMANN-LA ROCHE INC. (US) | 1981-06-30 | — | — | US | disclosed |