Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP3 | O14638 | 3/20 | 0.44 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.44 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 3/20 | 0.36 |
| ▸ | PPARA | Q07869 | 3/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.35 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25153267 | 1.00 | ENPP3 (0.44) | ENPP3ENPP1PIK3C3LMNAPPARG | |
| SCHEMBL7515939 | 0.84 | ENPP3 (0.50) | ENPP3ENPP1LMNATSHRPTGDR2 | |
| SCHEMBL23246934 | 0.83 | PIK3C3 (0.41) | PIK3C3LMNAPPARGPPARATSHR | |
| SCHEMBL1771967 | 0.81 | KMT2A (0.44) | PIK3C3LMNAPTGDR2NOD1SMN1; SMN2 | |
| SCHEMBL1359027 | 0.81 | ENPP3 (0.45) | ENPP3ENPP1LMNAHDAC8PTGDR2 | |
| SCHEMBL1773229 | 0.81 | CYP2C19 (0.51) | ENPP1PIK3C3LMNATSHRPTGDR2 | |
| SCHEMBL18918873 | 0.81 | ENPP3 (0.46) | ENPP3ENPP1LMNAHDAC8CXCL8 | |
| SCHEMBL18918772 | 0.80 | ENPP3 (0.46) | ENPP3ENPP1SMN1; SMN2MAPTCYP2C19 | |
| SCHEMBL4197377 | 0.79 | GRIN1 (0.39) | PIK3C3TSHRPTGDR2CYP2C19 | |
| SCHEMBL20502417 | 0.78 | ENPP3 (0.48) | ENPP3ENPP1LMNAPPARGTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023064218-A1 | TYRO3 INHIBITORS | Halia Therapeutics, Inc. (US) | 2023-04-20 | — | — | WO | disclosed |
| WO-2023049270-A1 | PYRROLE[2,3-B]PYRIDINE DERIVATIVES AS TYRO3 INHIBITORS | Halia Therapeutics, Inc. (US) | 2023-03-30 | — | — | WO | disclosed |