Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 8/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 8/20 | 0.39 |
| ▸ | PLK4 | O00444 | 2/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23246934 | 0.80 | PIK3C3 (0.41) | PIK3C3HTR6TSHRCYP2C19PTGDR2 | |
| SCHEMBL30280436 | 0.79 | ENPP3 (0.44) | PIK3C3TSHRCYP2C19PTGDR2 | |
| SCHEMBL25153267 | 0.79 | ENPP3 (0.44) | PIK3C3TSHRCYP2C19PTGDR2 | |
| SCHEMBL13854447 | 0.77 | PDGFRB (0.44) | GRIN1GRIN2BPDGFRBPDGFRAUSP2 | |
| SCHEMBL4202634 | 0.76 | CYP2C19 (0.53) | GRIN1GRIN2BPLK4HTR6HTR1A | |
| SCHEMBL1771967 | 0.76 | KMT2A (0.44) | PIK3C3CYP1A2CYP3A4CYP2C19PTGDR2 | |
| SCHEMBL1773229 | 0.75 | CYP2C19 (0.51) | PIK3C3HTR6CYP1A2CYP3A4TSHR | |
| SCHEMBL2043071 | 0.72 | PPARG (0.38) | HTR6TSHRPTGDRPTGDR2 | |
| SCHEMBL13854132 | 0.72 | PDGFRB (0.38) | GRIN1GRIN2BPDGFRBPDGFRACSNK1D | |
| SCHEMBL1778953 | 0.68 | NR1H2 (0.43) | HSD17B10PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7534800-B2 | 7-azaindoles as inhibitors of c-Jun N-terminal kinases for the treatment of neurodegenerative disorders | EISAI R & D DEVELOPMENT CO., LTD. (JP) | 2009-05-19 | — | — | US | disclosed |
| US-7534800-B2 | 7-azaindoles as inhibitors of c-Jun N-terminal kinases for the treatment of neurodegenerative disorders | EISAI R & D DEVELOPMENT CO., LTD. (JP) | 2009-05-19 | — | — | US | disclosed |
| EP-1490364-B1 | 7-AZAINDOLES AS INHIBITORS OF C-JUN N-TERMINAL KINASES FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | EISAI R&D MAN CO LTD (JP) | 2007-09-26 | — | — | EP | disclosed |
| US-20050272761-A1 | 7-azaindoles as inhibitors of c-jun n-terminal kinases for the treatment of neurodegenerative disorders | EISAI CO., LTD. (JP) | 2005-12-08 | — | — | US | disclosed |
| EP-1490364-A1 | 7-AZAINDOLES AS INHIBITORS OF C-JUN N-TERMINAL KINASES FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | Eisai Co., Ltd. (JP) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003082868-A1 | 7-AZAINDOLES AS INHIBITORS OF C-JUN N-TERMINAL KINASES FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | EISAI CO., LTD. (JP) | 2003-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272761-A1 | 7-azaindoles as inhibitors of c-jun n-terminal kinases for the treatment of neurodegenerative disorders | API5, MAPKAPK5, MAP3K5 | GRIN1 568/4885GRIN2B 901/4885PLK4 1126/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.