Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9920430 | 0.77 | ALDH1A1 (0.47) | KDM4EHTTAPOBEC3AAPOBEC3GJMJD6 | |
| SCHEMBL29913411 | 0.69 | MEN1 (0.43) | KDM4EHTTGABRA1GABRG2GABRB3 | |
| SCHEMBL1311420 | 0.68 | GABRA1 (0.43) | KDM4EHTTGABRA1GABRG2GABRB3 | |
| SCHEMBL13531221 | 0.67 | HCAR2 (0.42) | HTTGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL1496824 | 0.66 | MAPK1 (0.55) | HTTJMJD6L3MBTL1SMN1; SMN2CYP1A2 | |
| SCHEMBL2718057 | 0.66 | SRD5A2 (0.50) | KDM4ESMN1; SMN2ALDH1A1TSHRHSD17B10 | |
| SCHEMBL1947309 | 0.65 | — | — | |
| Water SCHEMBL23909393 | 0.64 | — | — | |
| Water SCHEMBL23909392 | 0.64 | NPSR1 (0.49) | KDM4EHTTAPOBEC3AAPOBEC3GL3MBTL1 | |
| SCHEMBL2003037 | 0.63 | TSHR (0.55) | KDM4EGABRA1GABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4143195-A1 | IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17 | Janssen Pharmaceutica NV (BE) | 2023-03-08 | — | — | EP | disclosed |