Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 3/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.35 |
| ▸ | TDO2 | P48775 | 5/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.32 |
| ▸ | HTR5A | P47898 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30284081 | 0.91 | PTGDR2 (0.39) | GRM2TDO2PTGDR2CNR2NPC1 | |
| SCHEMBL30283445 | 0.79 | ROCK1 (0.37) | GPBAR1 | |
| SCHEMBL30228195 | 0.79 | MEN1 (0.42) | GRM2PTGDR2CNR2NPC1 | |
| SCHEMBL30283297 | 0.73 | PARP1 (0.39) | GRM2TDO2 | |
| SCHEMBL30283713 | 0.70 | PRKAB2 (0.44) | MAPK14 | |
| SCHEMBL30283959 | 0.70 | PARP1 (0.49) | GRM2 | |
| SCHEMBL25276999 | 0.70 | GRM2 (0.39) | GRM2CNR2MAPK14GPBAR1HTR5A | |
| SCHEMBL30283574 | 0.70 | PARP15 (0.40) | MAPK14 | |
| SCHEMBL30283918 | 0.70 | ROCK1 (0.38) | — | |
| SCHEMBL30283577 | 0.69 | ALDH1A1 (0.39) | PTGDR2MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023034344-A1 | ISOQUINOLINONES AND QUINOLINONES AS MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |