Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTHFD2 | P13995 | 8/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.32 |
| ▸ | GHSR | Q92847 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23973519 | 1.00 | MTHFD2 (0.40) | MTHFD2MGLLROCK2CYP3A4PTGS1 | |
| SCHEMBL23972424 | 0.95 | MTHFD2 (0.37) | MTHFD2MGLL | |
| SCHEMBL30284061 | 0.95 | MTHFD2 (0.37) | MTHFD2MGLL | |
| SCHEMBL23973118 | 0.94 | MTHFD2 (0.38) | MTHFD2MGLLROCK2CYP3A4 | |
| SCHEMBL30284373 | 0.94 | MTHFD2 (0.38) | MTHFD2MGLLROCK2CYP3A4 | |
| SCHEMBL23973742 | 0.93 | MTHFD2 (0.39) | MTHFD2 | |
| SCHEMBL30283965 | 0.93 | MTHFD2 (0.39) | MTHFD2 | |
| SCHEMBL34464126 | 0.93 | MGLL (0.40) | MTHFD2MGLL | |
| SCHEMBL23972680 | 0.93 | MGLL (0.40) | MTHFD2MGLL | |
| SCHEMBL23972795 | 0.93 | MTHFD2 (0.41) | MTHFD2MGLLROCK2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4142874-B1 | PYRIMIDIN-4(3H)-ONE DERIVATIVES AS TRPV4 ANTAGONISTS | RAQUALIA PHARMA INC (JP) | 2026-04-22 | — | — | EP | claimed |
| CN-115427409-B | Pyrimidine-4 (3H) -one derivatives as TRPV4 antagonists | 拉夸里亚创药株式会社 | 2025-02-25 | — | — | CN | claimed |
| CN-115427409-B | Pyrimidine-4 (3H) -one derivatives as TRPV4 antagonists | 拉夸里亚创药株式会社 | 2025-02-25 | — | — | CN | disclosed |
| CN-115776890-A | TRPV4 inhibitors as therapeutic agents for eye diseases | 拉夸里亚创药株式会社 | 2023-03-10 | — | — | CN | disclosed |