Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 2/20 | 0.58 |
| ▸ | TRPV4 | Q9HBA0 | 4/20 | 0.56 |
| ▸ | CA12 | O43570 | 3/20 | 0.49 |
| ▸ | CA1 | P00915 | 3/20 | 0.49 |
| ▸ | CA2 | P00918 | 3/20 | 0.49 |
| ▸ | CA9 | Q16790 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | XBP1 | P17861 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | PDE2A | O00408 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2384992 | 0.91 | TACR3 (0.70) | TACR3TRPV4CA12CA1CA2 | |
| SCHEMBL30284215 | 0.91 | TACR3 (0.70) | TACR3TRPV4CA12CA1CA2 | |
| SCHEMBL6452631 | 0.74 | TACR3 (1.00) | TACR3LMNASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL22573242 | 0.73 | AURKA (0.58) | CA12CA1CA2CA9LMNA | |
| SCHEMBL30485644 | 0.73 | AURKA (0.58) | CA12CA1CA2CA9LMNA | |
| SCHEMBL2404540 | 0.72 | TRPV4 (1.00) | TACR3TRPV4 | |
| SCHEMBL2371586 | 0.72 | TRPV4 (0.88) | TACR3TRPV4 | |
| SCHEMBL2373465 | 0.71 | KDM4E (0.69) | CA12CA1CA2CA9LMNA | |
| SCHEMBL28984340 | 0.71 | TRPV4 (0.60) | TACR3TRPV4 | |
| SCHEMBL8617534 | 0.70 | CA12 (0.64) | TACR3CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025051930-A1 | PHARMACEUTICAL COMPOSITION COMPRISING TRPV4 INHIBITOR FOR USE IN THE PREVENTION OR TREATMENT OF CEREBRAL CAVERNOUS MALFORMATIONS (CCM) | UNIVERSITE GRENOBLE ALPES (FR) | 2025-03-13 | — | — | WO | disclosed |
| CN-115776890-A | TRPV4 inhibitors as therapeutic agents for eye diseases | 拉夸里亚创药株式会社 | 2023-03-10 | — | — | CN | disclosed |