Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 9/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | EDNRA | P25101 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | FRK | P42685 | 1/20 | 0.32 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1778905 | 0.76 | GABRA5 (0.54) | GABRA5MAPK14MAPK9MAPK10MAPK11 | |
| SCHEMBL1777145 | 0.76 | GABRA5 (0.48) | GABRA5MAPK14MAPK9MAPK10MAPK11 | |
| SCHEMBL21551844 | 0.71 | MAPK9 (0.46) | GABRA5MAPK14MAPK9MAPK10MAPK11 | |
| SCHEMBL1776597 | 0.71 | GABRA5 (0.52) | GABRA5MAPK1SMN1; SMN2POLBTDP1 | |
| SCHEMBL2814353 | 0.66 | HSP90AA1 (0.52) | MAPK14MAPK9MAPK10MAPK11CYP2D6 | |
| SCHEMBL30595872 | 0.66 | HSP90AA1 (0.52) | MAPK14MAPK9MAPK10MAPK11CYP2D6 | |
| SCHEMBL1874520 | 0.66 | MAPK14 (0.60) | GABRA5MAPK14MAPK9MAPK10MAPK11 | |
| SCHEMBL17622989 | 0.66 | KDM4E (0.41) | GABRA5MAPK14MAPK9MAPK10MAPK11 | |
| SCHEMBL1876030 | 0.65 | MAPK14 (0.75) | MAPK14MAPK9MAPK10MAPK11POLB | |
| SCHEMBL1880417 | 0.64 | MAPK14 (0.65) | MAPK14MAPK9MAPK10MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231651-A1 | ISOXAZOLO-PYRIDAZINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009071477-A1 | ISOXAZOLO-PYRIDAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-11 | — | — | WO | disclosed |