Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 12/20 | 0.58 |
| ▸ | FABP4 | P15090 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | UBE2N | P61088 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.52 |
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | PPARD | Q03181 | 1/20 | 0.52 |
| ▸ | PPARA | Q07869 | 1/20 | 0.52 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR1D | P28221 | 1/20 | 0.48 |
| ▸ | HTR1B | P28222 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3684432 | 1.00 | HTR6 (0.58) | HTR6FABP4KDM4EUBE2NL3MBTL1 | |
| SCHEMBL3621599 | 0.89 | HTR6 (0.68) | HTR6FABP4HTTPPARGPPARD | |
| SCHEMBL10823230 | 0.85 | HTR6 (0.56) | HTR6FABP4KDM4EUBE2NL3MBTL1 | |
| SCHEMBL4560894 | 0.85 | HTR6 (0.56) | HTR6KDM4EUBE2NL3MBTL1POLB | |
| SCHEMBL505125 | 0.85 | HTR6 (0.56) | HTR6KDM4EUBE2NL3MBTL1POLB | |
| SCHEMBL11218072 | 0.85 | HTR6 (0.59) | HTR6KDM4EUBE2NL3MBTL1POLB | |
| SCHEMBL30949526 | 0.85 | HTR6 (0.59) | HTR6KDM4EUBE2NL3MBTL1POLB | |
| SCHEMBL6570590 | 0.85 | HTR6 (0.76) | HTR6KDM4EUBE2NL3MBTL1POLB | |
| SCHEMBL30096985 | 0.85 | HTR6 (0.56) | HTR6KDM4EUBE2NL3MBTL1POLB | |
| SCHEMBL31092832 | 0.82 | HTR6 (0.58) | HTR6KDM4EUBE2NL3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4673137-A1 | NBD1 MODULATORS AND METHODS OF USING THE SAME | Sionna Therapeutics Inc. (US) | 2026-01-07 | — | — | EP | disclosed |
| WO-2024182736-A1 | NBD1 MODULATORS AND METHODS OF USING THE SAME | SIONNA THERAPEUTICS INC. (US) | 2024-09-06 | — | — | WO | disclosed |
| EP-4396176-A1 | INDOLE COMPOUNDS AND USES THEREOF IN THE TREATEMENT OF CYSTIC FIBROSIS | GENZYME CORPORATION (US) | 2024-07-10 | — | — | EP | disclosed |
| WO-2023034946-A1 | INDOLE COMPOUNDS AND USES THEREOF IN THE TREATEMENT OF CYSTIC FIBROSIS | GENZYME CORPORATION (US) | 2023-03-09 | — | — | WO | disclosed |