Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 9/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.33 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29336572 | 1.00 | SMN1; SMN2 (0.34) | SMN1; SMN2DGAT1NR1H2NR1H3GRIN2D | |
| SCHEMBL29337131 | 0.89 | GRIN2D (0.34) | DGAT1NR1H2NR1H3GRIN2DGRIN3B | |
| SCHEMBL29336743 | 0.87 | GRIN2D (0.33) | DGAT1NR1H2NR1H3GRIN2DGRIN3B | |
| SCHEMBL30285438 | 0.87 | GRIN2D (0.33) | DGAT1NR1H2NR1H3GRIN2DGRIN3B | |
| SCHEMBL29336752 | 0.87 | DGAT1 (0.35) | DGAT1NR1H2NR1H3GRIN2DGRIN3B | |
| SCHEMBL29336570 | 0.86 | DGAT1 (0.34) | DGAT1NR1H2NR1H3GRIN2DGRIN3B | |
| SCHEMBL29336566 | 0.85 | KDM4E (0.35) | DGAT1NR1H2NR1H3GRIN2DGRIN3B | |
| SCHEMBL29336575 | 0.85 | CHEK2 (0.36) | DGAT1NR1H2NR1H3GRIN2DGRIN3B | |
| SCHEMBL29237763 | 0.85 | NR1H2 (0.35) | DGAT1NR1H2NR1H3HRH1HRH4 | |
| SCHEMBL30217055 | 0.85 | NR1H2 (0.35) | DGAT1NR1H2NR1H3HRH1HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4396176-A1 | INDOLE COMPOUNDS AND USES THEREOF IN THE TREATEMENT OF CYSTIC FIBROSIS | GENZYME CORPORATION (US) | 2024-07-10 | — | — | EP | disclosed |
| WO-2023034946-A1 | INDOLE COMPOUNDS AND USES THEREOF IN THE TREATEMENT OF CYSTIC FIBROSIS | GENZYME CORPORATION (US) | 2023-03-09 | — | — | WO | disclosed |