Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.37 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.34 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | SDHB | P21912 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | GCK | P35557 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29336583 | 1.00 | BACE1 (0.37) | BACE1BACE2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL29336940 | 0.90 | BRD4 (0.32) | BRD4GCKPTGS2 | |
| SCHEMBL30285454 | 0.90 | BRD4 (0.32) | BRD4GCKPTGS2 | |
| SCHEMBL29336584 | 0.90 | BACE1 (0.36) | BACE1BACE2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL30285506 | 0.90 | BACE1 (0.36) | BACE1BACE2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL30285407 | 0.85 | GRIN2D (0.33) | BACE1BACE2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL29336768 | 0.85 | GRIN2D (0.33) | BACE1BACE2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL29336772 | 0.83 | PIN1 (0.36) | BACE1BACE2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL30285518 | 0.83 | PIN1 (0.36) | BACE1BACE2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL29336566 | 0.82 | KDM4E (0.35) | BACE1BACE2GRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4396176-A1 | INDOLE COMPOUNDS AND USES THEREOF IN THE TREATEMENT OF CYSTIC FIBROSIS | GENZYME CORPORATION (US) | 2024-07-10 | — | — | EP | disclosed |
| WO-2023034946-A1 | INDOLE COMPOUNDS AND USES THEREOF IN THE TREATEMENT OF CYSTIC FIBROSIS | GENZYME CORPORATION (US) | 2023-03-09 | — | — | WO | disclosed |