Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29336758 | 0.87 | ALDH1A1 (0.50) | ALDH1A1TSHRHTTCYP2C19HIF1A | |
| SCHEMBL29336761 | 0.81 | ALDH1A1 (0.41) | ALDH1A1TSHRHTTCYP2C19HIF1A | |
| SCHEMBL31172766 | 0.74 | CYP2C19 (0.60) | ALDH1A1TSHRHTTCYP2C19HIF1A | |
| SCHEMBL28831712 | 0.74 | ALDH1A1 (0.42) | ALDH1A1TSHRHTTCYP2C19HIF1A | |
| SCHEMBL15116240 | 0.74 | CYP2C19 (0.46) | ALDH1A1CYP2C19HIF1AKMT2AMAPT | |
| SCHEMBL10865897 | 0.73 | TAAR1 (0.48) | ALDH1A1TSHRHTTCYP2C19HIF1A | |
| SCHEMBL9317928 | 0.73 | MAPK1 (0.41) | ALDH1A1TSHRHTTCYP2C19HIF1A | |
| SCHEMBL2927687 | 0.73 | ALDH1A1 (0.62) | ALDH1A1TSHRHTTCYP2C19HIF1A | |
| SCHEMBL1035978 | 0.73 | ALDH1A1 (0.53) | ALDH1A1TSHRHTTCYP2C19HIF1A | |
| SCHEMBL14850480 | 0.73 | ALDH1A1 (0.62) | ALDH1A1TSHRHTTCYP2C19HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4396176-A1 | INDOLE COMPOUNDS AND USES THEREOF IN THE TREATEMENT OF CYSTIC FIBROSIS | GENZYME CORPORATION (US) | 2024-07-10 | — | — | EP | disclosed |
| WO-2023034946-A1 | INDOLE COMPOUNDS AND USES THEREOF IN THE TREATEMENT OF CYSTIC FIBROSIS | GENZYME CORPORATION (US) | 2023-03-09 | — | — | WO | disclosed |