Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 19/20 | 0.53 |
| ▸ | F2 | P00734 | 5/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30217327 | 0.88 | F10 (0.50) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL29237602 | 0.88 | F10 (0.50) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL27276124 | 0.86 | F10 (0.48) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL30967772 | 0.86 | F10 (0.48) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL29336700 | 0.86 | F10 (0.46) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL29336712 | 0.84 | F10 (0.46) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL30285660 | 0.84 | F10 (0.46) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL29336749 | 0.83 | F10 (0.44) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL29336704 | 0.83 | F10 (0.43) | F10F2 | |
| SCHEMBL30217071 | 0.83 | TRPA1 (0.34) | F10F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4396176-A1 | INDOLE COMPOUNDS AND USES THEREOF IN THE TREATEMENT OF CYSTIC FIBROSIS | GENZYME CORPORATION (US) | 2024-07-10 | — | — | EP | disclosed |
| WO-2023034946-A1 | INDOLE COMPOUNDS AND USES THEREOF IN THE TREATEMENT OF CYSTIC FIBROSIS | GENZYME CORPORATION (US) | 2023-03-09 | — | — | WO | disclosed |