Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 17/20 | 0.46 |
| ▸ | F2 | P00734 | 7/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29336712 | 1.00 | F10 (0.46) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL27276337 | 0.89 | ASH1L (0.43) | F10F2 | |
| SCHEMBL30750124 | 0.87 | F10 (0.32) | F10F2 | |
| SCHEMBL27282951 | 0.86 | AKR1C3 (0.43) | F10 | |
| SCHEMBL29237602 | 0.85 | F10 (0.50) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL30217327 | 0.85 | F10 (0.50) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL30805103 | 0.84 | TRPA1 (0.33) | — | |
| SCHEMBL27265131 | 0.84 | TRPA1 (0.33) | — | |
| SCHEMBL30285603 | 0.84 | F10 (0.53) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL30967772 | 0.84 | F10 (0.48) | F10F2PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4396176-A1 | INDOLE COMPOUNDS AND USES THEREOF IN THE TREATEMENT OF CYSTIC FIBROSIS | GENZYME CORPORATION (US) | 2024-07-10 | — | — | EP | disclosed |
| WO-2023034946-A1 | INDOLE COMPOUNDS AND USES THEREOF IN THE TREATEMENT OF CYSTIC FIBROSIS | GENZYME CORPORATION (US) | 2023-03-09 | — | — | WO | disclosed |