Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 4/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | KIF11 | P52732 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | RBP4 | P02753 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13651799 | 0.84 | TSHR (0.38) | TSHRALDH1A1TDP1CA2HTR2C | |
| SCHEMBL1498947 | 0.79 | HTR2C (0.50) | TSHRTDP1HTR2CHTR2BRBP4 | |
| SCHEMBL5698914 | 0.79 | HTR2C (0.50) | TSHRTDP1HTR2CHTR2BRBP4 | |
| SCHEMBL11937218 | 0.78 | ALDH1A1 (0.39) | TSHRALDH1A1TDP1CA2HTR2C | |
| SCHEMBL37732 | 0.77 | TSHR (0.57) | TSHRTDP1CHRM2CHRM4CHRM1 | |
| SCHEMBL17865245 | 0.75 | SMN1; SMN2 (0.36) | TSHRALDH1A1CA2HTR2CHTR2B | |
| SCHEMBL11937219 | 0.75 | ALDH1A1 (0.36) | TSHRALDH1A1TDP1CA2HTR2C | |
| SCHEMBL8524358 | 0.71 | TAAR1 (0.52) | TSHRALDH1A1HTR2CHTR2BCHRM2 | |
| SCHEMBL8525267 | 0.71 | TAAR1 (0.52) | TSHRALDH1A1HTR2CHTR2BCHRM2 | |
| SCHEMBL168917 | 0.71 | TAAR1 (0.52) | TSHRALDH1A1HTR2CHTR2BCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100210617-A1 | Aryl-Alkylamines And Heteroaryl-Alkylamines As Protein Kinase Inhibitors | ASTEX THERAPEUTICS LIMITED (GB) | 2010-08-19 | — | — | US | disclosed |
| EP-1904451-A1 | ARYL-ALKYLAMINES AND HETEROARYL-ALKYLAMINES AS PROTEIN KINASE INHIBITORS | Astex Therapeutics Limited (GB) | 2008-04-02 | — | — | EP | disclosed |
| WO-2006136830-A1 | ARYL-ALKYLAMINES AND HETEROARYL-ALKYLAMINES AS PROTEIN KINASE INHIBITORS | ASTEX THERAPEUTICS LIMITED (GB) | 2006-12-28 | — | — | WO | disclosed |
| WO-1989006661-A1 | MODIFIED ADVANCED EPOXY RESINS | THE DOW CHEMICAL COMPANY (US) | 1989-07-27 | — | — | WO | disclosed |
| WO-1989006662-A1 | MODIFIED ADVANCED EPOXY RESINS | THE DOW CHEMICAL COMPANY (US) | 1989-07-27 | — | — | WO | disclosed |
| EP-0324389-A2 | Modified advanced epoxy resins | THE DOW CHEMICAL COMPANY (US) | 1989-07-19 | — | — | EP | disclosed |
| EP-0324405-A2 | Modified advanced epoxy resins | THE DOW CHEMICAL COMPANY (US) | 1989-07-19 | — | — | EP | disclosed |
| US-4835225-A | Modified advanced epoxy resins | THE DOW CHEMICAL COMPANY (US) | 1989-05-30 | — | — | US | disclosed |
| US-4820784-A | CURED HOMO- AND COPOLYMERS OF POLYEPOXIDES, EPOXY RESINS AND POLYETHERS MODIFIED BY PHOSPHORIC ACID; LOW VISCOSITY; FLEXIBLE CHEMICAL RESISTANCE COATINGS | THE DOW CHEMICAL COMPANY (US) | 1989-04-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100210617-A1 | Aryl-Alkylamines And Heteroaryl-Alkylamines As Protein Kinase Inhibitors | ERBB2, ABL1, GRK2 | TSHR 406/4885ALDH1A1 4220/4885TDP1 3440/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.