Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.64 |
| ▸ | TSHR | P16473 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.48 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28978282 | 0.83 | RIPK1 (0.83) | RIPK1TSHRALDH1A1MAPK1KDM4E | |
| SCHEMBL30289640 | 0.80 | RIPK1 (0.66) | RIPK1TSHRALDH1A1KDM4EHCRTR2 | |
| SCHEMBL28978285 | 0.78 | RIPK1 (1.00) | RIPK1ALDH1A1MAPK1KDM4EMAPT | |
| SCHEMBL28978314 | 0.78 | RIPK1 (0.72) | RIPK1TSHRMAPK1CHRM2CHRM3 | |
| SCHEMBL28978316 | 0.78 | RIPK1 (0.79) | RIPK1TSHRALDH1A1MAPK1KDM4E | |
| SCHEMBL30289718 | 0.77 | RIPK1 (0.66) | RIPK1TSHRHCRTR2MEN1KMT2A | |
| SCHEMBL28978327 | 0.77 | ALDH1A1 (0.50) | RIPK1TSHRALDH1A1MAPK1KDM4E | |
| SCHEMBL28978328 | 0.77 | RIPK1 (0.71) | RIPK1TSHRALDH1A1MAPK1MEN1 | |
| SCHEMBL28978283 | 0.76 | RIPK1 (0.80) | RIPK1TSHRMAPK1KDM4EDDB1 | |
| SCHEMBL6412938 | 0.75 | EGLN1 (0.52) | ALDH1A1KDM4EHCRTR2EGLN1DDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115894489-A | Inhibitor of receptor interaction protein kinase 1, preparation method and application thereof | 中国药科大学 | 2023-04-04 | — | — | CN | disclosed |