Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 4/20 | 0.63 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.63 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.63 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.63 |
| ▸ | DRD1 | P21728 | 3/20 | 0.63 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.63 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.63 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.63 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.63 |
| ▸ | HTR1A | P08908 | 2/20 | 0.63 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.63 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.63 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.63 |
| ▸ | DRD3 | P35462 | 2/20 | 0.63 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.63 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.63 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.63 |
| ▸ | KCNK2 | O95069 | 2/20 | 0.63 |
| ▸ | HTR2C | P28335 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3034389 | 0.88 | TBXA2R (0.50) | ABCB11TBXA2RADRA1ASLC6A3DRD1 | |
| SCHEMBL6297478 | 0.85 | ABCB11 (0.52) | ABCB11TBXA2RADRA1ASLC6A3DRD1 | |
| SCHEMBL11736568 | 0.84 | TBXA2R (0.64) | ABCB11TBXA2RADRA1ASLC6A3DRD1 | |
| SCHEMBL8258913 | 0.84 | HTR1A (0.58) | ABCB11TBXA2RADRA1ASLC6A3DRD1 | |
| SCHEMBL29676073 | 0.83 | KDM4E (0.68) | ABCB11TBXA2RADRA1ASLC6A3DRD1 | |
| SCHEMBL3035724 | 0.83 | KDM4E (0.68) | ABCB11TBXA2RADRA1ASLC6A3DRD1 | |
| SCHEMBL5477290 | 0.82 | ABCB11 (0.90) | ABCB11TBXA2RADRA1ASLC6A3DRD1 | |
| SCHEMBL30958564 | 0.82 | ABCB11 (0.90) | ABCB11TBXA2RADRA1ASLC6A3DRD1 | |
| SCHEMBL10746465 | 0.82 | ABCB11 (0.64) | ABCB11TBXA2RADRA1ASLC6A3DRD1 | |
| SCHEMBL29676385 | 0.82 | ABCB11 (0.64) | ABCB11TBXA2RADRA1ASLC6A3DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100215735-A1 | Compounds for Inhibiting Beta-Amyloid Production and Methods of Identifying the Compounds | MULLAN MICHAEL J | 2010-08-26 | — | — | US | disclosed |
| US-20100215735-A1 | Compounds for Inhibiting Beta-Amyloid Production and Methods of Identifying the Compounds | MULLAN MICHAEL J | 2010-08-26 | — | — | US | disclosed |
| US-20100216784-A1 | Compounds for Inhibiting Beta-Amyloid Production and Methods of Identifying the Compounds | MULLAN MICHAEL J | 2010-08-26 | — | — | US | disclosed |
| US-20100216784-A1 | Compounds for Inhibiting Beta-Amyloid Production and Methods of Identifying the Compounds | MULLAN MICHAEL J | 2010-08-26 | — | — | US | disclosed |
| US-20100216784-A1 | Compounds for Inhibiting Beta-Amyloid Production and Methods of Identifying the Compounds | MULLAN MICHAEL J | 2010-08-26 | — | — | US | disclosed |
| US-20100215735-A1 | Compounds for Inhibiting Beta-Amyloid Production and Methods of Identifying the Compounds | MULLAN MICHAEL J | 2010-08-26 | — | — | US | disclosed |
| US-20080058330-A1 | Compounds and Combinations Thereof for Inhibiting Beta-Amyloid Production and Methods of Use Thereof | ROSKAMP RESEARCH LLC (US) | 2008-03-06 | — | — | US | disclosed |
| US-20080058330-A1 | Compounds and Combinations Thereof for Inhibiting Beta-Amyloid Production and Methods of Use Thereof | ROSKAMP RESEARCH LLC (US) | 2008-03-06 | — | — | US | disclosed |
| US-20080058330-A1 | Compounds and Combinations Thereof for Inhibiting Beta-Amyloid Production and Methods of Use Thereof | ROSKAMP RESEARCH LLC (US) | 2008-03-06 | — | — | US | disclosed |
| WO-2008006070-A2 | COMPOUNDS AND COMBINATIONS THEREOF FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS OF USE THEREOF | ROSKAMP RESEARCH LLC (US) | 2008-01-10 | — | — | WO | disclosed |
| US-20070191409-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | ROSKAMP RESEARCH LLC | 2007-08-16 | — | — | US | disclosed |
| US-20070191409-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | ROSKAMP RESEARCH LLC | 2007-08-16 | — | — | US | disclosed |
| US-20070191409-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | ROSKAMP RESEARCH LLC | 2007-08-16 | — | — | US | disclosed |
| US-20070185130-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | ROSKAMP RESEARCH LLC | 2007-08-09 | — | — | US | disclosed |
| US-20070185130-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | ROSKAMP RESEARCH LLC | 2007-08-09 | — | — | US | disclosed |
| US-20070185130-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | ROSKAMP RESEARCH LLC | 2007-08-09 | — | — | US | disclosed |
| US-20070037855-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | ALZHEIMER'S INSTITUTE OF AMERICA, INC. | 2007-02-15 | — | — | US | disclosed |
| US-20070037855-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | ALZHEIMER'S INSTITUTE OF AMERICA, INC. | 2007-02-15 | — | — | US | disclosed |
| US-20060188938-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | ARCHER PHARMACEUTICALS, INC. | 2006-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080058330-A1 | Compounds and Combinations Thereof for Inhibiting Beta-Amyloid Production and Methods of Use Thereof | APP, PSEN1, PSEN2 | ABCB11 2253/4885TBXA2R 1443/4885ADRA1A 1533/4885 |
| US-20070191409-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | APP, PSEN1, PSEN2 | ABCB11 1711/4885TBXA2R 1184/4885ADRA1A 1028/4885 |
| US-20070185130-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | APP, PSEN1, PSEN2 | ABCB11 1711/4885TBXA2R 1184/4885ADRA1A 1028/4885 |
| US-20070037855-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | APP, PSEN1, PSEN2 | ABCB11 1711/4885TBXA2R 1184/4885ADRA1A 1028/4885 |
| US-20100216784-A1 | Compounds for Inhibiting Beta-Amyloid Production and Methods of Identifying the Compounds | APP, PSEN1, PSEN2 | ABCB11 1711/4885TBXA2R 1184/4885ADRA1A 1028/4885 |
| US-20060188938-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | APP, PSEN1, PSEN2 | ABCB11 1711/4885TBXA2R 1184/4885ADRA1A 1028/4885 |
| US-20100215735-A1 | Compounds for Inhibiting Beta-Amyloid Production and Methods of Identifying the Compounds | APP, PSEN1, PSEN2 | ABCB11 1711/4885TBXA2R 1184/4885ADRA1A 1028/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.