Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 4/20 | 0.36 |
| ▸ | JAK1 | P23458 | 4/20 | 0.36 |
| ▸ | TYK2 | P29597 | 4/20 | 0.36 |
| ▸ | JAK3 | P52333 | 4/20 | 0.36 |
| ▸ | LPL | P06858 | 4/20 | 0.33 |
| ▸ | LIPG | Q9Y5X9 | 4/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | F11 | P03951 | 1/20 | 0.31 |
| ▸ | P4HB | P07237 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17005480 | 0.89 | FFAR1 (0.52) | FFAR1LPLLIPGIRAK4F11 | |
| SCHEMBL19713715 | 0.87 | FFAR1 (0.50) | FFAR1JAK2JAK1TYK2JAK3 | |
| SCHEMBL17815970 | 0.87 | FFAR1 (0.50) | FFAR1JAK2JAK1TYK2JAK3 | |
| SCHEMBL875957 | 0.85 | FFAR1 (0.51) | FFAR1LPLLIPGIRAK4 | |
| SCHEMBL17815976 | 0.83 | FFAR1 (0.49) | FFAR1LPLLIPGIRAK4 | |
| SCHEMBL22527489 | 0.82 | FFAR1 (0.52) | FFAR1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22527457 | 0.82 | FFAR1 (0.52) | FFAR1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22527458 | 0.82 | FFAR1 (0.52) | FFAR1JAK2JAK1TYK2JAK3 | |
| SCHEMBL1989062 | 0.81 | FFAR1 (0.50) | FFAR1LPLLIPGIRAK4 | |
| SCHEMBL17352230 | 0.81 | FFAR1 (0.48) | FFAR1LPLLIPGIRAK4F11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4355742-A1 | SUBSTITUTED PYRIMIDINYL-PYRAZOLES AS CDK2 INHIBITORS | Blueprint Medicines Corporation (US) | 2024-04-24 | — | — | EP | disclosed |
| WO-2022266190-A1 | SUBSTITUTED PYRIMIDINYL-PYRAZOLES AS CDK2 INHIBITORS | BLUEPRINT MEDICINES CORPORATION (US) | 2022-12-22 | — | — | WO | disclosed |