Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.63 |
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.52 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.50 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22165412 | 1.00 | TP53 (0.63) | TP53LMNAMTNR1APOLBROCK2 | |
| SCHEMBL28379701 | 1.00 | TP53 (0.63) | TP53LMNAMTNR1APOLBROCK2 | |
| SCHEMBL1519082 | 1.00 | TP53 (0.63) | TP53LMNAMTNR1APOLBROCK2 | |
| SCHEMBL1519319 | 0.89 | TP53 (0.51) | TP53LMNAMTNR1APOLBMAPT | |
| SCHEMBL16303419 | 0.89 | MTNR1A (0.66) | TP53LMNAMTNR1APOLBROCK2 | |
| SCHEMBL24440178 | 0.89 | TP53 (0.51) | TP53LMNAMTNR1APOLBMAPT | |
| SCHEMBL29633457 | 0.89 | TP53 (0.51) | TP53LMNAMTNR1APOLBMAPT | |
| SCHEMBL13362778 | 0.87 | TP53 (0.62) | TP53LMNAMTNR1APOLBROCK2 | |
| SCHEMBL30290663 | 0.87 | TP53 (0.62) | TP53LMNAMTNR1APOLBROCK2 | |
| SCHEMBL1519402 | 0.86 | TP53 (0.49) | TP53LMNAMTNR1APOLBROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113227086-B | N- (4- (oxazol-5-yl) phenyl) chroman-3-carboxamide derivatives and related compounds as stimulators of production of retinal precursor cells for the treatment of neuroretinal disorders | 内生疗法公司 | 2024-07-26 | — | — | CN | disclosed |
| EP-4167999-A1 | NEW COMPOUNDS AND THEIR USE AS THERAPEUTICALLY ACTIVE SUBSTANCES IN THE TREATMENT AND/OR PREVENTION OF DISEASES INVOLVING THE RETINAL PIGMENT EPITHELIUM | Endogena Therapeutics, Inc. (US) | 2023-04-26 | — | — | EP | disclosed |
| CN-115916192-A | Novel compounds and their use as therapeutically active substances for the treatment and/or prophylaxis of diseases in which the retinal pigment epithelium is involved | 内生疗法公司 | 2023-04-04 | — | — | CN | disclosed |