⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14323902 | 0.86 | NR1H2 (0.31) | — | |
| SCHEMBL2937743 | 0.84 | — | — | |
| SCHEMBL2878056 | 0.84 | — | — | |
| SCHEMBL303431 | 0.79 | GPR119 (0.36) | — | |
| SCHEMBL304532 | 0.77 | DGAT1 (0.31) | — | |
| SCHEMBL2883155 | 0.76 | GPR119 (0.39) | — | |
| SCHEMBL5727764 | 0.71 | MEN1 (0.38) | — | |
| SCHEMBL3355846 | 0.67 | USP2 (0.33) | — | |
| SCHEMBL4258348 | 0.66 | MEN1 (0.35) | — | |
| SCHEMBL3353671 | 0.66 | TP53 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093238-B2 | Fused thiazole derivatives as kinase inhibitors | UCB PHARMA S.A. (BE) | 2012-01-10 | — | — | US | disclosed |
| US-20100069361-A1 | Fused Thiazole Derivatives as Kinase Inhibitors | UCB PHARMA S.A. (BE) | 2010-03-18 | — | — | US | disclosed |
| EP-1581529-A1 | BENZOXAZINES AND DERIVATIVES THEREOF AS INHIBITORS OF PI3KS | WARNER-LAMBERT COMPANY (US) | 2005-10-05 | — | — | EP | disclosed |
| US-20040138199-A1 | Benzoxazines and derivatives thereof as therapeutic agents | GOGLIOTTI ROCCO DEAN (US) | 2004-07-15 | — | — | US | disclosed |
| WO-2004056820-A1 | BENZOXAZINES AND DERIVATIVES THEREOF AS INHIBITORS OF PI3KS | WARNER-LAMBERT COMPANY LLC (US) | 2004-07-08 | — | — | WO | disclosed |