Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 5/20 | 0.59 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | AKR1B10 | O60218 | 3/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | AKR1C1 | Q04828 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.59 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.59 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.59 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.59 |
| ▸ | DHFR | P00374 | 1/20 | 0.59 |
| ▸ | MPO | P05164 | 1/20 | 0.59 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22853331 | 1.00 | AKR1C3 (0.59) | AKR1C3AKR1C2MEN1AKR1B10PTGS2 | |
| SCHEMBL22853383 | 0.89 | P2RY4 (0.56) | AKR1C3AKR1C2MEN1AKR1B10PTGS2 | |
| SCHEMBL30294653 | 0.89 | P2RY4 (0.56) | AKR1C3AKR1C2MEN1AKR1B10PTGS2 | |
| SCHEMBL22720122 | 0.87 | FABP4 (0.66) | AKR1C3AKR1C2MEN1AKR1B10PTGS2 | |
| SCHEMBL6141067 | 0.86 | FABP4 (0.62) | AKR1C3AKR1C2MEN1AKR1B10PTGS2 | |
| SCHEMBL22853413 | 0.85 | MAPT (0.55) | PTGS2KMT2ALMNACYP1A2TDP1 | |
| SCHEMBL30294693 | 0.85 | MAPT (0.55) | PTGS2KMT2ALMNACYP1A2TDP1 | |
| SCHEMBL30294529 | 0.85 | DHODH (0.56) | AKR1C3AKR1C2MEN1KMT2AFABP4 | |
| SCHEMBL22852994 | 0.85 | DHODH (0.56) | AKR1C3AKR1C2MEN1KMT2AFABP4 | |
| SCHEMBL16489007 | 0.84 | MAPT (0.62) | AKR1C3AKR1C2MEN1AKR1B10PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230103791-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2023-04-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230103791-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | SCN8A, SCN1A, SCN1B | AKR1C3 2437/4885AKR1C2 2468/4885MEN1 1826/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.