Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.50 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.47 |
| ▸ | KCNMA1 | Q12791 | 3/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.45 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.45 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9403860 | 1.00 | KDM4E (0.59) | KDM4EHSD17B10EPHX1GRIK1KMT2A | |
| SCHEMBL29683063 | 0.87 | KDM4E (0.62) | KDM4EHSD17B10KMT2AHDAC1HDAC6 | |
| SCHEMBL3873599 | 0.87 | KDM4E (0.62) | KDM4EHSD17B10KMT2AHDAC1HDAC6 | |
| SCHEMBL3782005 | 0.84 | KDM4E (0.68) | KDM4EHSD17B10EPHX1KMT2AHDAC1 | |
| SCHEMBL29177448 | 0.82 | GRIK1 (0.54) | KDM4EGRIK1KMT2ANPC1RAB9A | |
| SCHEMBL29791333 | 0.82 | GRIK1 (0.54) | KDM4EGRIK1KMT2ANPC1RAB9A | |
| SCHEMBL8955980 | 0.82 | SMN1; SMN2 (0.55) | KDM4EKMT2AHDAC1HDAC6CA1 | |
| SCHEMBL30748254 | 0.82 | SMN1; SMN2 (0.55) | KDM4EKMT2AHDAC1HDAC6CA1 | |
| SCHEMBL20560214 | 0.82 | GRIK1 (0.50) | GRIK1KMT2ANPC1RAB9ATMPRSS4 | |
| SCHEMBL2388970 | 0.82 | EPHX1 (0.70) | KDM4EHSD17B10EPHX1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4702021-A1 | COMPOUNDS CAPABLE OF MODULATING GPR65 | Pathios Therapeutics Limited (GB) | 2026-03-04 | — | — | EP | disclosed |
| WO-2024224064-A1 | COMPOUNDS CAPABLE OF MODULATING GPR65 | Pathios Therapeutics Limited (GB) | 2024-10-31 | — | — | WO | disclosed |
| EP-4419203-A1 | TRICYCLIC GPR65 MODULATORS | Pathios Therapeutics Limited (GB) | 2024-08-28 | — | — | EP | disclosed |
| CN-118451080-A | Tricyclic GPR65 modulators | 帕蒂奥斯治疗有限公司 | 2024-08-06 | — | — | CN | disclosed |
| WO-2023067322-A1 | TRICYCLIC GPR65 MODULATORS | Pathios Therapeutics Limited (GB) | 2023-04-27 | — | — | WO | disclosed |