Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.37 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.37 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.37 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.37 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.37 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.36 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.36 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26456968 | 1.00 | CSNK2A1 (0.44) | CSNK2A1ALDH1A1HSD17B10CYP2A6ADORA2A | |
| SCHEMBL16119858 | 0.85 | ALDH1A1 (0.43) | CSNK2A1ALDH1A1HSD17B10CYP2A6ADORA2A | |
| SCHEMBL12364208 | 0.84 | ALDH1A1 (0.50) | CSNK2A1ALDH1A1HSD17B10CYP2A6PRKAB2 | |
| SCHEMBL990770 | 0.82 | ALDH1A1 (0.48) | ALDH1A1HSD17B10PTGS1PTGS2TSHR | |
| SCHEMBL8734809 | 0.82 | CYP2A6 (0.48) | CSNK2A1CYP2A6ADORA2AADORA1PRKAB2 | |
| SCHEMBL26457501 | 0.81 | NPC1 (0.42) | ADORA2AGAAPDE3BPDE3A | |
| SCHEMBL30296553 | 0.81 | NPC1 (0.42) | ADORA2AGAAPDE3BPDE3A | |
| SCHEMBL2265147 | 0.80 | CSNK2A1 (0.47) | CSNK2A1ALDH1A1HSD17B10CYP2A6PRKAB2 | |
| SCHEMBL10922908 | 0.78 | CSNK2A1 (0.48) | CSNK2A1ALDH1A1HSD17B10CYP2A6ADORA1 | |
| SCHEMBL21999626 | 0.78 | ALDH1A1 (0.48) | ALDH1A1HSD17B10PTGS1PTGS2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4419203-A1 | TRICYCLIC GPR65 MODULATORS | Pathios Therapeutics Limited (GB) | 2024-08-28 | — | — | EP | disclosed |
| CN-118451080-A | Tricyclic GPR65 modulators | 帕蒂奥斯治疗有限公司 | 2024-08-06 | — | — | CN | disclosed |
| WO-2023067322-A1 | TRICYCLIC GPR65 MODULATORS | Pathios Therapeutics Limited (GB) | 2023-04-27 | — | — | WO | disclosed |