Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA7 | P43166 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3413587 | 1.00 | SOS1 (0.44) | SOS1SLC6A4SLC6A3SMN1; SMN2NPC1 | |
| SCHEMBL31055681 | 0.84 | SOS1 (0.49) | SOS1SLC6A4SLC6A3SMN1; SMN2NPC1 | |
| SCHEMBL19971599 | 0.84 | SOS1 (0.49) | SOS1SLC6A4SLC6A3SMN1; SMN2NPC1 | |
| SCHEMBL31283849 | 0.82 | SOS1 (0.44) | SOS1SLC6A4SLC6A3ALDH1A1NOTUM | |
| SCHEMBL16048883 | 0.82 | SOS1 (0.44) | SOS1SLC6A4SLC6A3ALDH1A1NOTUM | |
| SCHEMBL14719381 | 0.81 | SLC6A4 (0.41) | SOS1SLC6A4SLC6A3SMN1; SMN2NPC1 | |
| SCHEMBL21621554 | 0.81 | SLC6A4 (0.45) | SOS1SLC6A4SLC6A3SMN1; SMN2NPC1 | |
| SCHEMBL20903073 | 0.81 | XDH (0.49) | SOS1SMN1; SMN2ALDH1A1MAPTCA12 | |
| SCHEMBL18878112 | 0.81 | CES2 (0.44) | SLC6A4SLC6A3SMN1; SMN2NPC1CASP3 | |
| SCHEMBL935778 | 0.81 | HSD17B10 (0.49) | SOS1SLC6A3ALDH1A1NOTUMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4402143-A1 | SPIROCYCLIC COMPOUNDS | Astrazeneca AB (SE) | 2024-07-24 | — | — | EP | disclosed |
| WO-2023036974-A1 | SPIROCYCLIC COMPOUNDS | ASTRAZENECA AB (SE) | 2023-03-16 | — | — | WO | disclosed |