Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH3A1 | P30838 | 4/20 | 0.46 |
| ▸ | PPARG | P37231 | 2/20 | 0.45 |
| ▸ | PPARD | Q03181 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | NOD1 | Q9Y239 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.44 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | NMT1 | P30419 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26620188 | 1.00 | ALDH3A1 (0.46) | ALDH3A1PPARGPPARDLMNANOD1 | |
| SCHEMBL30296816 | 0.88 | PPARG (0.47) | ALDH3A1PPARGPPARDLMNANOD1 | |
| SCHEMBL26620218 | 0.88 | PPARG (0.47) | ALDH3A1PPARGPPARDLMNANOD1 | |
| SCHEMBL7214465 | 0.88 | PPARG (0.46) | ALDH3A1PPARGPPARDLMNANOD1 | |
| SCHEMBL3531055 | 0.81 | PPARG (0.71) | PPARGPPARDPPARA | |
| SCHEMBL16235830 | 0.76 | PPARG (0.46) | ALDH3A1PPARGPPARDLMNANOD1 | |
| SCHEMBL26620160 | 0.76 | NOD1 (0.64) | ALDH3A1PPARGPPARDLMNANOD1 | |
| SCHEMBL30647189 | 0.76 | NOD1 (0.57) | ALDH3A1PPARGPPARDLMNANOD1 | |
| SCHEMBL7116279 | 0.76 | NOD1 (0.57) | ALDH3A1PPARGPPARDLMNANOD1 | |
| SCHEMBL7213488 | 0.75 | PPARG (0.48) | ALDH3A1PPARGPPARDLMNANOD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4402143-A1 | SPIROCYCLIC COMPOUNDS | Astrazeneca AB (SE) | 2024-07-24 | — | — | EP | disclosed |
| CN-117916241-A | Spiro compounds | 阿斯利康(瑞典)有限公司 | 2024-04-19 | — | — | CN | disclosed |
| WO-2023036974-A1 | SPIROCYCLIC COMPOUNDS | ASTRAZENECA AB (SE) | 2023-03-16 | — | — | WO | disclosed |