Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EML4 | Q9HC35 | 7/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 7/20 | 0.46 |
| ▸ | AXL | P30530 | 9/20 | 0.42 |
| ▸ | ETV6 | P41212 | 6/20 | 0.42 |
| ▸ | FLT3 | P36888 | 8/20 | 0.42 |
| ▸ | RET | P07949 | 7/20 | 0.42 |
| ▸ | ROS1 | P08922 | 7/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | CIT | O14578 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | GAK | O14976 | 1/20 | 0.37 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.37 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.37 |
| ▸ | BUB1 | O43683 | 1/20 | 0.37 |
| ▸ | SNRNP200 | O75643 | 1/20 | 0.37 |
| ▸ | STK16 | O75716 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30300959 | 0.88 | EML4 (0.47) | EML4ALKAXLETV6FLT3 | |
| SCHEMBL30300927 | 0.86 | EML4 (0.56) | EML4ALKAXLETV6FLT3 | |
| SCHEMBL30300980 | 0.85 | LRRK2 (0.46) | EML4ALKAXLETV6FLT3 | |
| SCHEMBL31436402 | 0.74 | EML4 (0.56) | EML4ALKAXLETV6FLT3 | |
| SCHEMBL26702903 | 0.73 | EML4 (0.39) | EML4ALKAXLETV6FLT3 | |
| SCHEMBL25808963 | 0.72 | SMN1; SMN2 (0.36) | — | |
| SCHEMBL29944842 | 0.72 | EML4 (0.44) | EML4ALKAXLETV6FLT3 | |
| SCHEMBL30300861 | 0.69 | AXL (0.64) | EML4ALKAXLETV6FLT3 | |
| SCHEMBL30151513 | 0.68 | EML4 (0.50) | EML4ALKAXLETV6FLT3 | |
| SCHEMBL25184619 | 0.68 | MAPK1 (0.39) | EML4ALKAXLETV6FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4392409-A1 | PYRAZINE COMPOUNDS AS IRREVERSIBLE INHIBITORS OF FLT3 | Biomea Fusion, Inc. (US) | 2024-07-03 | — | — | EP | disclosed |
| WO-2023027966-A1 | PYRAZINE COMPOUNDS AS IRREVERSIBLE INHIBITORS OF FLT3 | BIOMEA FUSION, INC. (US) | 2023-03-02 | — | — | WO | disclosed |