Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EML4 | Q9HC35 | 4/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.44 |
| ▸ | AXL | P30530 | 6/20 | 0.41 |
| ▸ | FLT3 | P36888 | 5/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.41 |
| ▸ | MERTK | Q12866 | 1/20 | 0.41 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.41 |
| ▸ | ETV6 | P41212 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 4/20 | 0.40 |
| ▸ | ROS1 | P08922 | 4/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30151513 | 0.89 | EML4 (0.50) | EML4ALKAXLFLT3TYRO3 | |
| SCHEMBL30300959 | 0.79 | EML4 (0.47) | EML4ALKAXLFLT3ETV6 | |
| SCHEMBL31498503 | 0.74 | MAPK1 (0.49) | EML4ALKMAPK1PDE4B | |
| SCHEMBL30300927 | 0.72 | EML4 (0.56) | EML4ALKAXLFLT3ETV6 | |
| SCHEMBL30300980 | 0.72 | LRRK2 (0.46) | EML4ALKAXLFLT3ETV6 | |
| SCHEMBL30301017 | 0.72 | EML4 (0.46) | EML4ALKAXLFLT3TYRO3 | |
| SCHEMBL29582918 | 0.72 | HCAR3 (0.49) | MAPK1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL16048397 | 0.72 | HCAR3 (0.49) | MAPK1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL31498509 | 0.71 | EML4 (0.49) | EML4ALKAXLFLT3ETV6 | |
| SCHEMBL17075516 | 0.70 | HCAR3 (0.48) | MAPK1HDAC3HDAC1HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115124590-B | PROTAC compounds for targeted degradation of FLT3-ITD mutant proteins, and preparation method and application thereof | 武汉大学中南医院 | 2024-10-22 | — | — | CN | disclosed |
| CN-115124590-A | PROTAC compound for targeted degradation of FLT3-ITD mutant protein and preparation method and application thereof | 武汉大学中南医院 | 2022-09-30 | — | — | CN | disclosed |