Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.51 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.51 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.51 |
| ▸ | MC4R | P32245 | 1/20 | 0.46 |
| ▸ | CFTR | P13569 | 1/20 | 0.46 |
| ▸ | TACR1 | P25103 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.45 |
| ▸ | STS | P08842 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL114538 | 1.00 | ALDH1A1 (0.54) | ALDH1A1LMNAKDM4EGPR119MAPT | |
| SCHEMBL6628461 | 0.95 | MAPT (0.57) | ALDH1A1LMNAKDM4EGPR119MAPT | |
| SCHEMBL14453584 | 0.87 | GPR119 (0.55) | ALDH1A1LMNAGPR119MAPTSMARCA2 | |
| SCHEMBL3923112 | 0.86 | GPR119 (0.54) | ALDH1A1LMNAGPR119MAPTTACR1 | |
| SCHEMBL4422111 | 0.86 | GPR119 (0.54) | ALDH1A1LMNAGPR119MAPTSMARCA2 | |
| SCHEMBL3922455 | 0.86 | GPR119 (0.69) | ALDH1A1LMNAGPR119MAPTMC4R | |
| SCHEMBL31142873 | 0.86 | GPR119 (0.69) | ALDH1A1LMNAGPR119MAPTMC4R | |
| SCHEMBL115105 | 0.85 | GPR119 (0.53) | ALDH1A1LMNAGPR119MAPTSMARCA2 | |
| SCHEMBL13076730 | 0.85 | GPR119 (0.53) | ALDH1A1LMNAGPR119MAPTSMARCA2 | |
| SCHEMBL31250021 | 0.85 | ALDH1A1 (0.57) | ALDH1A1LMNAMAPTSMARCA2SMARCA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4182311-B1 | 1-METHYL-1H-PYRAZOL-3-YL DERIVATIVES FOR USE IN THE TREATMENT OF NEOVASCULAR DISEASES | EXONATE LTD (GB) | 2025-06-04 | — | — | EP | disclosed |
| US-20240300929-A1 | 1-METHYL-1H-PYRAZOL-3-YL DERIVATIVES FOR USE IN THE TREATMENT OF NEOVASCULAR DISEASES | EXONATE LTD (GB) | 2024-09-12 | — | — | US | disclosed |
| US-12024504-B2 | 1-methyl-1H-pyrazol-3-yl derivatives for use in the treatment of neovascular diseases | EXONATE LIMITED (GB) | 2024-07-02 | — | — | US | disclosed |
| US-20220411412-A1 | 1-METHYL-1H-PYRAZOL-3-YL DERIVATIVES FOR USE IN THE TREATMENT OF NEOVASCULAR DISEASES | EXONATE LIMITED (GB) | 2022-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220411412-A1 | 1-METHYL-1H-PYRAZOL-3-YL DERIVATIVES FOR USE IN THE TREATMENT OF NEOVASCULAR DISEASES | VEGFA, FLT4, FLT1 | ALDH1A1 1874/4885LMNA 2008/4885KDM4E 1107/4885 |
| US-20240300929-A1 | 1-METHYL-1H-PYRAZOL-3-YL DERIVATIVES FOR USE IN THE TREATMENT OF NEOVASCULAR DISEASES | VEGFA, FLT4, FLT1 | ALDH1A1 1874/4885LMNA 2008/4885KDM4E 1107/4885 |
| US-12024504-B2 | 1-methyl-1H-pyrazol-3-yl derivatives for use in the treatment of neovascular diseases | VEGFA, FLT4, FLT1 | ALDH1A1 1874/4885LMNA 2008/4885KDM4E 1107/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.