Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | MAP3K11 | Q16584 | 5/20 | 0.35 |
| ▸ | MTOR | P42345 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.31 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.31 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL977387 | 0.88 | CYP1A2 (0.49) | CYP1A2MAP3K11MTORSMN1; SMN2CYP3A4 | |
| SCHEMBL978018 | 0.88 | CYP1A2 (0.49) | CYP1A2MAP3K11MTORSMN1; SMN2CYP3A4 | |
| SCHEMBL977388 | 0.88 | CYP1A2 (0.49) | CYP1A2MAP3K11MTORSMN1; SMN2CYP3A4 | |
| SCHEMBL978045 | 0.86 | CYP1A2 (0.40) | CYP1A2MAP3K11MTORSMN1; SMN2HPGD | |
| SCHEMBL978047 | 0.86 | CYP1A2 (0.40) | CYP1A2MAP3K11MTORSMN1; SMN2HPGD | |
| SCHEMBL974737 | 0.83 | CYP1A2 (0.38) | CYP1A2MAP3K11MTORSMN1; SMN2 | |
| SCHEMBL482137 | 0.83 | CYP1A2 (0.38) | CYP1A2MAP3K11MTORSMN1; SMN2 | |
| SCHEMBL975801 | 0.83 | CYP1A2 (0.38) | CYP1A2MAP3K11MTORSMN1; SMN2 | |
| SCHEMBL976856 | 0.76 | CYP1A2 (0.50) | CYP1A2MAP3K11MTOR | |
| SCHEMBL482066 | 0.74 | TLR9 (0.45) | MAP3K11MTORSMN1; SMN2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293761-B2 | Certain chemical entities, compositions and methods | CYTOKINETICS, INC. (US) | 2012-10-23 | — | — | US | disclosed |
| US-20100210645-A1 | Certain Chemical Entities, Compositions and Methods | CYTOKINETICS, INC. | 2010-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100210645-A1 | Certain Chemical Entities, Compositions and Methods | TNNC1, TNNI3, TNNT2 | CYP1A2 3794/4885MAP3K11 1398/4885MTOR 607/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.