Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 6/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.35 |
| ▸ | ELANE | P08246 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.32 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.32 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23887248 | 1.00 | GPR35 (0.40) | GPR35CCNE2CDK1CDK4CCNB1 | |
| SCHEMBL23887280 | 0.87 | GPR35 (0.35) | GPR35CCNE2CDK1CDK4CCNB1 | |
| SCHEMBL30064040 | 0.82 | PIK3CA (0.39) | CCNE2CDK1CDK4CCNB1CCND1 | |
| SCHEMBL23887051 | 0.82 | PIK3CA (0.39) | CCNE2CDK1CDK4CCNB1CCND1 | |
| SCHEMBL23886969 | 0.81 | CCNE2 (0.35) | GPR35CCNE2CDK1CDK4CCNB1 | |
| SCHEMBL30307588 | 0.81 | CCNE2 (0.35) | GPR35CCNE2CDK1CDK4CCNB1 | |
| SCHEMBL23887366 | 0.78 | LOXL2 (0.54) | GPR35CCNE2CDK1CDK4CCNB1 | |
| SCHEMBL30307518 | 0.78 | PIK3CA (0.35) | CCNE2CDK1CDK4CCNB1CCND1 | |
| SCHEMBL23887148 | 0.78 | PIK3CA (0.35) | CCNE2CDK1CDK4CCNB1CCND1 | |
| SCHEMBL23887035 | 0.77 | PRKDC (0.42) | GPR35CCNE2CDK1CDK4CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115956075-A | Allosteric enone inhibitors of phosphoinositide 3-kinases (PI 3 ks) for the treatment of diseases associated with PI3K modulation | 佩特拉制药公司 | 2023-04-11 | — | — | CN | disclosed |