Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.35 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | RORA | P35398 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | RORB | Q92753 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30309025 | 1.00 | HTR2A (0.40) | HTR2AHTR2CSLC6A4ADORA3ALDH1A1 | |
| SCHEMBL30309012 | 0.89 | P2RX7 (0.45) | HTR2AHTR2CSLC6A4NLRP3 | |
| SCHEMBL29195760 | 0.86 | HTR2A (0.44) | HTR2AHTR2CSLC6A4ADORA3ALDH1A1 | |
| SCHEMBL30309013 | 0.85 | LMNA (0.38) | ALDH1A1KDM4EHSD17B10KMT2A | |
| SCHEMBL29195818 | 0.83 | HTR2A (0.45) | HTR2AHTR2CSLC6A4ADORA3ALDH1A1 | |
| SCHEMBL29195771 | 0.79 | HTR2A (0.38) | HTR2AHTR2CSLC6A4ADORA3ALDH1A1 | |
| SCHEMBL29195750 | 0.76 | P2RX7 (0.48) | HTR2AHTR2CSLC6A4ALDH1A1HSD17B10 | |
| SCHEMBL20548477 | 0.76 | P2RX7 (0.52) | HTR2AHTR2CSLC6A4ALDH1A1KDM4E | |
| SCHEMBL30314503 | 0.76 | P2RX7 (0.52) | HTR2AHTR2CSLC6A4ALDH1A1KDM4E | |
| SCHEMBL29195813 | 0.74 | EPHX2 (0.44) | ALDH1A1KDM4ENPSR1HSD17B10DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4396181-A1 | 2,4-DIHYDRO-3H-1,2,4-TRIAZOL-3-ONE P2X7 ANTAGONISTS | Breye Therapeutics ApS (DK) | 2024-07-10 | — | — | EP | disclosed |
| WO-2023031319-A1 | 2,4-DIHYDRO-3H-1,2,4-TRIAZOL-3-ONE P2X7 ANTAGONISTS | AXXAM S.P.A. (IT) | 2023-03-09 | — | — | WO | disclosed |