SCHEMBL30309227

SCHEMBL30309227

N=C(N)NCCC[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O

nearest known ligand 0.67

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ NPY4R P50391 17/20 0.67
▸ NPY1R P25929 10/20 0.67
▸ NPY5R Q15761 9/20 0.67
▸ NPY2R P49146 6/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30540722 0.97 NPY4R (0.63) NPY4RNPY1RNPY5RNPY2R
SCHEMBL29936549 0.95 NPY4R (0.61) NPY4RNPY1RNPY5RNPY2R
SCHEMBL30427476 0.95 NPY4R (0.61) NPY4RNPY1RNPY5RNPY2R
SCHEMBL30309304 0.93 NPY4R (0.65) NPY4RNPY1RNPY5RNPY2R
SCHEMBL29868927 0.92 NPY4R (0.57) NPY4RNPY1RNPY5RNPY2R
SCHEMBL29576743 0.91 NPY4R (0.54) NPY4RNPY1RNPY5RNPY2R
SCHEMBL30592738 0.90 NPY4R (0.61) NPY4RNPY1RNPY5RNPY2R
SCHEMBL30589456 0.90 NPY4R (0.61) NPY4RNPY1RNPY5RNPY2R
SCHEMBL29461983 0.90 NPY4R (0.61) NPY4RNPY1RNPY5RNPY2R
SCHEMBL30974032 0.90 NPY4R (0.54) NPY4RNPY1RNPY5RNPY2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11612633-B2 Methods and compositions for preventing or treating ophthalmic conditions STEALTH BIOTHERAPEUTICS INC. (US) 2023-03-28 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11612633-B2 Methods and compositions for preventing or treating ophthalmic conditions CRYAA, CRYAB, IAPP NPY4R 379/4885NPY1R 144/4885NPY5R 343/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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