Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIK2 | Q9H0K1 | 2/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | SIK1 | P57059 | 1/20 | 0.43 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.43 |
| ▸ | FGFR4 | P22455 | 14/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 11/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 6/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.32 |
| ▸ | KDR | P35968 | 2/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | FYN | P06241 | 1/20 | 0.30 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.30 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.30 |
| ▸ | PRKACA | P17612 | 1/20 | 0.30 |
| ▸ | PRKACG | P22612 | 1/20 | 0.30 |
| ▸ | PRKACB | P22694 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30309533 | 0.88 | SIK2 (0.51) | SIK2CSF1RSIK1SIK3FGFR4 | |
| SCHEMBL23978120 | 0.88 | SIK2 (0.51) | SIK2CSF1RSIK1SIK3FGFR4 | |
| SCHEMBL30309486 | 0.86 | SIK2 (0.46) | SIK2CSF1RSIK1SIK3FGFR4 | |
| SCHEMBL25882416 | 0.86 | SIK2 (0.46) | SIK2CSF1RSIK1SIK3FGFR4 | |
| SCHEMBL25881926 | 0.81 | CSF1R (0.60) | SIK2CSF1RSIK1SIK3FGFR4 | |
| SCHEMBL30309539 | 0.81 | CSF1R (0.60) | SIK2CSF1RSIK1SIK3FGFR4 | |
| SCHEMBL25313125 | 0.79 | SIK2 (0.73) | SIK2CSF1RSIK1SIK3EGFR | |
| SCHEMBL25882519 | 0.79 | SIK2 (0.69) | SIK2CSF1RSIK1SIK3FGFR4 | |
| SCHEMBL23978372 | 0.79 | SIK2 (0.68) | SIK2CSF1RSIK1SIK3FGFR4 | |
| SCHEMBL23978178 | 0.79 | SIK2 (0.51) | SIK2CSF1RSIK1SIK3FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4143191-A2 | BICYCLIC KINASE INHIBITORS AND USES THEREOF | iOmx Therapeutics AG (DE) | 2023-03-08 | — | — | EP | disclosed |