SCHEMBL30309528

SCHEMBL30309528

CN1C(=O)N(c2c(CF)csc2Cl)Cc2cnc(Cl)nc21

nearest known ligand 0.38

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
FGFR4 P22455 17/20 0.38
FGFR1 P11362 2/20 0.38
LCK P06239 1/20 0.37
MAPK14 Q16539 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23978368 1.00 FGFR4 (0.38) FGFR4FGFR1LCKMAPK14SMN1; SMN2
SCHEMBL25882482 0.85 FGFR4 (0.37) FGFR4FGFR1LCKMAPK14
SCHEMBL30309508 0.81 FGFR4 (0.40) FGFR4FGFR1
SCHEMBL23978369 0.81 FGFR4 (0.40) FGFR4FGFR1
SCHEMBL25882416 0.79 SIK2 (0.46) FGFR4FGFR1LCKMAPK14
SCHEMBL30309486 0.79 SIK2 (0.46) FGFR4FGFR1LCKMAPK14
SCHEMBL25314439 0.74 CSF1R (0.57) FGFR4
SCHEMBL25882488 0.74 SMN1; SMN2 (0.32) SMN1; SMN2
SCHEMBL16071527 0.72 FGFR4 (0.65) FGFR4FGFR1
SCHEMBL16071406 0.68 FGFR4 (0.72) FGFR4FGFR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4143191-A2 BICYCLIC KINASE INHIBITORS AND USES THEREOF iOmx Therapeutics AG (DE) 2023-03-08 EP disclosed