Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 17/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 11/20 | 0.40 |
| ▸ | SIK2 | Q9H0K1 | 2/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 7/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 6/20 | 0.34 |
| ▸ | EGFR | P00533 | 3/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.34 |
| ▸ | KDR | P35968 | 3/20 | 0.34 |
| ▸ | FYN | P06241 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | EPHB3 | P54753 | 2/20 | 0.34 |
| ▸ | PRKACA | P17612 | 1/20 | 0.34 |
| ▸ | PRKACG | P22612 | 1/20 | 0.34 |
| ▸ | PRKACB | P22694 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | SIK1 | P57059 | 1/20 | 0.33 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30309508 | 1.00 | FGFR4 (0.40) | FGFR4FGFR1SIK2FGFR2FGFR3 | |
| SCHEMBL25882416 | 0.90 | SIK2 (0.46) | FGFR4FGFR1SIK2FGFR2FGFR3 | |
| SCHEMBL30309486 | 0.90 | SIK2 (0.46) | FGFR4FGFR1SIK2FGFR2FGFR3 | |
| SCHEMBL23978368 | 0.81 | FGFR4 (0.38) | FGFR4FGFR1 | |
| SCHEMBL30309528 | 0.81 | FGFR4 (0.38) | FGFR4FGFR1 | |
| SCHEMBL25882482 | 0.79 | FGFR4 (0.37) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL4686776 | 0.79 | FGFR4 (0.47) | FGFR4FGFR1SIK2FGFR2FGFR3 | |
| SCHEMBL25313384 | 0.79 | CSF1R (0.62) | SIK2EGFRCSF1RSIK1SIK3 | |
| SCHEMBL23978120 | 0.76 | SIK2 (0.51) | FGFR4FGFR1SIK2FGFR2FGFR3 | |
| SCHEMBL30309533 | 0.76 | SIK2 (0.51) | FGFR4FGFR1SIK2FGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021219731-A2 | BICYCLIC KINASE INHIBITORS AND USES THEREOF | IOMX THERAPEUTICS AG (DE) | 2021-11-04 | — | — | WO | disclosed |